移至主內容

謝政哲

謝政哲
教授
國立陽明大學博士
台中榮總研究大樓R116A/R201分子生化實驗室
(04)23592525#4052/4061
shiehjj@dragon.nchu.edu.tw

研究領域

  • 類鐸受體7活化劑imiquimod誘發細胞凋亡(apoptosis)與細胞自噬(autophagy)之分子機制及其與免疫反應之交互作用。
  • Imiquimod誘發乾癬致病機制, 動物模式之建立及藥物篩選。
  • Imiquimod誘導能量代謝基因表現差異之相關性及調控機制。
  • 老藥新用於癌症治療方法之研究與開發。

教授科目

  • 上學期-基因及幹細胞醫學科技特論 (一)(2學分)
  • 上學期-老化研究特論(2學分)
  • 上學期-細胞自噬特論(2學分)
  • 上學期-先天免疫學特論(2學分)
  • 下學期-基因及幹細胞醫學科技特論 (二) (2學分)
  • 下學期-生物技術在臨床醫學之應用(2學分)
  • 下學期-醣類生化及代謝疾病特論(2學分)
  • 下學期-人類遺傳疾病特論(2學分)

簡要經歷

  • 教授/國立中興大學生物醫學研究所/ 2016-
  • 副教授/國立中興大學生物醫學研究所/ 2012-2016
  • 助理教授/國立中興大學生物醫學研究所/ 2009-2012
  • 助理教授/國立中興大學醫學科技研究所/ 2006-2009
  • 助理教授/私立長榮大學醫學研究所/ 2003-2006 
  • 兼任研究員/彰化基督教醫院教研部/ 2003-2006 
  • 博士後研究/美國國家衛生研究院NIH/ 2000-2003
  • 博士後研究/中央研究院生物農業科學研究所籌備處/ 1998-2000
  • 博士後研究/台北榮民總醫院小兒部/ 1997-1998
  • 博士/國立陽明大學微生物及免疫研究所/ 1991-1997

獲獎項目

  • 104年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會論文競賽優良論文(2016)
  • 104年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會海報競賽佳作(2016)
  • 102年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會論文競賽優良論文(2014)
  • 101年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會海報競賽佳作(2013)
  • 101年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會論文競賽第二名(2013)
  • 指導博士班研究生黃士維同學獲得2013年中興大學生物醫學研究所retreat meeting暨博士班學生進度報告競賽第一名(2013)
  • 100年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」論文競賽第二名(2012)
  • 指導博士班研究生黃士維同學獲得2012年中興大學生物醫學研究所retreat meeting暨博士班學生進度報告競賽第一名(2012)
  • 指導博士班研究生黃士維同學獲得2011年22nd World Congress of Dermatology (Seoul, Korea), Silver Award of e-poster (2011)
  • 指導博士班研究生黃士維同學獲得2011年中興大學生物醫學研究所retreat meeting暨博士班學生進度報告競賽第二名(2011)
  • 指導碩士班研究生黃士維同學獲得九十八年基因體與蛋白質體學術研討會壁報比賽第二名(2009)
  • 指導碩士班研究生劉光庭同學獲得九十七年醫學科技研究所論文競賽第一名(2008)
  • 私立長榮大學醫學研究所所績優導師(2005)
  • 美國國家衛生研究院(NIH)博士後研究Fellowship Award (2000)
  • 中央研究院一般博士後研究學者(1999)

學術著作

期刊論文

  • Chuang KC, Chen FW, Tsai MH*, Shieh JJ*. EGR-1 plays a protective role in AMPK inhibitor compound C-induced apoptosis through ROS-induced ERK activation in skin cancer cells. Oncology Letters. 2020, Accepted.*Corresponding author.
  • Chung MC, Yu TM, Wu MJ, Chuang YW, Muo CH, Chen CH, Chang CH, Shieh JJ, Hung PH, Chen JW, Chung CJ. Is combined peritoneal dialysis and hemodialysis redundant? A nationwide study from Taiwan. BMC Nephrol. 2020, 21(1): 348. 
  • Kao JK, Wang SC, Ho LW, Huang SW, Lee CH, Lee MS, Yang RC, Shieh JJ*. M2-like polarization of THP-1 monocyte-derived macrophages under chronic iron overload. Annals of Hematology. 2020, 99(3):431-441.  *Corresponding author.
  • Wang ST, Huang SW, Liu KT, Lee TY, Shieh JJ*, Wu CY*. Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway. Cell Death Discovery. 2020, 6:17.  *Corresponding author.
  • Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ*. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells. Journal of Dermatological Science. 2020, 98(2): 152-162.*Corresponding author.
  • Huang SW, Wang ST, Chang SH, Chung KC, Wang HY, Kao JK, Liang SM, Wu CY, Kao SF, Chen YJ, Shieh JJ*. Imiquimod exerts antitumor effects by inducing immunogenic cell death and is enhanced by the glycolytic inhibitor 2-deoxy-glucose. Journal of Investigative Dermatology. 2020, 140: 1771-1783. *Corresponding author.
  • Kao JK, Hsu TF, Lee MS, Su TC, Lee CH, Hsu CS, Shieh JJ, Wang JY, Yang RC. Subcutaneous injection of recombinant heat shock protein 70 ameliorates atopic dermatitis skin lesions in a mouse model.Kaohsiung J Med Sci. 2020, 36: 186-195. 
  • Chen YJ*, Ho HJ, Tseng CH, Lai ZL, Shieh JJ, Wu CY. Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients. Exp Dermatol. 2018, 27(12): 1336-1343. 
  • Chang SH, Huang SW, Wang ST, Chung KC, Hsieh CW, Kao JK, Chen YJ, Wu CY*, Shieh JJ*. Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells. Journal of Dermatological Science. 2017, 87(2):138-148. *Corresponding author.
  • ​Wang ST, Ho HJ, Lin JT, Shieh JJ*, Wu CY*.  Simvastatin-induced cell cycle arrest though inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells. Cell Death and Disease. 2017, 8, e2626. *Corresponding author.
  • Wu CY, Chang YT, Juan CK, Shieh JJ, Lin YP, Liu HN, Lin JT, Chen YJ. Risk of inflammatory bowel disease in rosacea patients: results from a nationwide cohort study. Journal of the American Academy of Dermatology. 2017, 76: 911-917.
  • Huang SW, Chen YJ, Wang ST, Ho LW, Kao JK, Takahashi M, Narita M, Wu CY, Cheng HY, Shieh JJ*. Azithromycin Impairs TLR7 Signaling in Dendritic Cells and Improves the Severity of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice. Journal of Dermatological Science. 2016, 84(1):59-70. *Corresponding author.
  • Kao JK, Wang SC, Ho LW, Huang SW, Chang SH, Yang RC, Ke YY, Wu CY, Wang JY*, Shieh JJ*. Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification. Plos One. 2016, 11(5): e0156713 *Corresponding author.
  • Wu CY, Chang YT, Juan CK, Shen JL, Lin YP, Shieh JJ, Liu HN, Chen YJ*. Depression and insomnia in patients with psoriasis and psoriatic arthritis taking tumor necrosis factor antagonists. Medicine. 2016, 95(22):e3816.
  • Huang SW, Chang SH, Mu SW, Jiang HY, Wang ST, Kao JK, Huang JL, Wu CY, Chen YJ, Shieh JJ*. Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line. Journal of Dermatological Science. 2016, 81(3): 182-91. *Corresponding author.
  • Daniel J. Klionsky and 2170 others. Guidelines for the use and interpretation of assays for monitoring autophagy (3th edition). Autophagy. 2016; 12(1): 1-222.
  • Kao JK, Lee CH, Lee MS, Hsu CS, Tsao LY, Tsai YG, Shieh JJ*, Yang RC*. Heat shock pretreatment reduces expression and release of TSLP from keratinocytes under Th2 environment. Pediatric Allergy and Immunology. 2016; 27(1): 62-9. *Corresponding author.
  • Wang ST, Huang SW, Kao JK, Liang SM, Chen YJ, Chen YY, Wu CY, Shieh JJ*. Imiquimod-induced AMPK activation causes translation attenuation and apoptosis but not autophagy. Journal of Dermatological Science. 2015; 78(2): 108-16. *Corresponding author.
  • Chang CH, Chan PC, Li JR, Chen CJ, Shieh JJ, Fu YC, Chen HC, Wu MJ. Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation. Oncotarget. 2015; 6(3):1478~1489.
  • Wu CY, Shieh JJ, Shen JL, Liu YY, Chang YT, Chen YJ. Association between anti-diabetic drugs and psoriasis risk in diabetic patients: results from a nationwide nested case control study. Journal of the American Academy of Dermatology. 2015; 72(1):123~130.
  • Huang SW, Kao JK, Wu CY, Wang ST, Lee HC, Liang SM, Chen YJ, Shieh JJ*. Targeting Aerobic Glycolysis and HIF-1 alpha Expression Enhance Imiquimod-induced Apoptosis in Cancer Cells. Oncotarget. 2014; 5(5): 1363~1381 *Corresponding author.
  • Chen HP#, Shieh JJ#, Chang CC, Chen TT, Lin JT, Wu MS, Lin HJ, Wu CY. Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies. Gut. 2013;62(4):606-15.  #Co-first author.
  • Yang SY, Wan HM, Wu TW, Chen YJ, Shieh JJ, Lin JH, Ho TF, Luo RJ, Hsieh TJ, Chang CC. Subamolide B isolated from medicinal plant Cinnamomum subavenium induces cytotoxicity in human cutaneous squamous cell carcinoma cells through mitochondrial and CHOP-dependent cell death pathways. Evid Based Complement Alternat Med. 2013, 2013:630415.
  • Huang SW, Wu CY, Wang YT, Kao JK, Lin CC, Chang CC, Mu SW, Chen YY, Chiu HW, Chang CH, Liang SM, Chen YJ, Huang JL, Shieh JJ*.  p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Toxicology and Applied Pharmacology. 2013, 267: 113-124. *Corresponding author.
  • Chen YJ, Wu CS, Shieh JJ, Wu JH, Chen HY, Chung TW, Chen YK, Lin CC. Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Anti-Leukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells. Evid Based Complement Alternat Med. 2013; 2013:124747. 
  • Shieh JJ, Lu YH, Huang SW, Huang YH, Sun CH, Chiou HJ, Liu C, Lo MY, Lin CY, Niu DM. Misdiagnosis as steatohepatitis in a family with mild glycogen storage disease type 1a. Gene. 2012; 509(1): 154-7. Daniel J. Klionsky and 1268 others. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012; 8(4): 445-544.
  • Hsieh HY, Shieh JJ, Chen CJ, Pan MY, Yang SY, Lin SC, Chang JS, Lee AY, Chang CC. Prodigiosin down-regulates SKP2 to induce p27(KIP1) stabilization and antiproliferation in human lung adenocarcinoma cells. Br J Pharmacol. 2012; 166:2095-2108.
  • Huang SW,  Chang CC, Lin CC, Tsai JJ, Chen YJ, Wu CY, Liu KT, Shieh JJ*. Mcl-1 determines the imiquimod-induced apoptosis but not imiquimod-induced autophagy in skin cancer cells. Journal of Dermatological Science. 2012; 65(3):170-8. *Corresponding author.
  • Wu CS#, Chen YJ#, Chen JJ, Shieh JJ, Huang CH, Lin PS, Chang GC, Chang JT, Lin CC. Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo. Evid Based Complement Alternat Med. 2012, 2012:818261. #Co-first auther.
  • Huang SW, Liu KT, Chang CC, Chen YJ, Wu CY, Tsai JJ, Lu WC, Wang YT, Liu CM, Shieh JJ*.  Imiquimod Simultaneously Induces Autophagy and Apoptosis in Human Basal Cell Carcinoma Cells. Brit J Dermatol. 2010; 163(2):310-20. *Corresponding author. 
  • Shieh JJ*, Liu KT, Huang SW, Chen YJ, Hsieh TY. Modification of alternative splicing of Mcl-1 pre-mRNA using antisense morpholino oligonucleotides induces apoptosis in basal cell carcinoma cells. J Invest Dermatol. 2009; 129(10):2497-506. *Corresponding author.
  • Lin MT, Shieh JJ, Chang JHM, Chang SW, Chen TC, Hsu WH. Early detection of adrenocortical carcinoma in a child with Li-Fraumeni syndrome. Pediatric Blood & Cancer. 2009; 52(4): 541-544.
  • Chiou YL, Shieh JJ, Lin CY.  Blocking of Akt/NF-kappaB signaling by pentoxifylline inhibits platelet-derived growth factor-stimulated proliferation in Brown Norway rat airway smooth muscle cells. Pediatr Res. 2006;60(6):657-62.
  • Tsai YG, Chien JW, Chen WL, Shieh JJ, Lin CY.  Induced apoptosis of TH2 lymphocytes in asthmatic children treated with Dermatophagoides pteronyssinus immunotherapy. Pediatr Allergy Immunol. 2005;16(7):602-8.
  • Nguyen AD, Pan CJ, Shieh JJ, Chou JY: Increased cellular cholesterol efflux in glycogen storage disease type Ia mice: a potential mechanism that protects against premature atherosclerosis. FEBS letters 2005; 579(21):4713-8.
  • Shieh JJ, Pan CJ, Mansfield BC, Chou JY: In islet-specific glucose-6-phosphatase-related protein, the beta cell antigenic sequence that is targeted in diabetes is not responsible for the loss of phosphohydrolase activity. Diabetologia. 2005; 48(9):1851-9.
  • Shieh JJ, Pan CJ, Mansfield BC, Chou JY : A potential new role for muscle in blood glucose homeostasis. J Biol Chem 2004; 279(25):26215-26219. 
  • Shieh JJ, Pan CJ, Mansfield BC, Chou JY: The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane. FEBS letters 2004; 562:160-164.
  • Ghosh A#, Shieh JJ#, Pan CJ, Chou JY:  Histidine-167 is the phosphate acceptor in glucose-6-phosphatase-beta forming a phosphohistidine-enzyme intermediate during catalysis. J Biol Chem 2004; 279(13): 12479-12483. # Co-first author. 
  • Shieh JJ, Pan CJ, Mansfield BC, Chou JY:  A glucose-6-phosphate hydrolase, widely expressed outside the liver, can explain age-dependent resolution of hypoglycemia in glycogen storage disease type Ia. J Biol Chem 2003; 278(47): 47098-47103. 
  • Wang JH, Liang CM, Peng JM, Shieh JJ, Jong MH, Lin YL, Sieber M, Liang SM: Induction of immunity in swine by purified recombinant VP1 of foot-and-mouth disease virus. Vaccine 2003; 21:3721-9. 
  • Chen LY#, Shieh JJ, Lin B, Pan CJ, Gao JL, Murphy PM, Roe TF, Moses S, Ward JM, Lee EJ, Westphal H, Mansfield BC, Chou JY: Imapired glucose homeostasis, neutrophil recruitment, chemokine action and calcium flux in glycogen storage disease type 1b mice.  Hum Mol Genet 2003; 12: 2547-2558. #Co-first auther. 
  • Chen LY, Pan CJ, Shieh JJ, Chou JY: Structure-function analysis of the glucose-6-phosphate transporter deficient in glycogen storage disease type Ib. Hum Mol Genet 2002; 11: 3199-3207. 
  • Sun MS, Pan CJ, Shieh JJ, Ghosh A, Chen LY, Mansfield BC, Ward JM, Byrne BJ, Chou JY: Sustained hepatic and renal glucose-6-phosphatase expression corrects glycogen storage disease type Ia in mice. Hum Mol Genet 2002; 11: 2155-2164. 
  • Ghosh A, Shieh JJ, Pan CJ, Sun MS, Chou JY:  The catalytic center of glucose-6-phosphatase: His176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis. J Biol Chem 2002; 277: 32837-32842. 
  • Shieh JJ, Teraioglu M, Hirawa H, Marsh J, Pan CJ, Chen LY, Chou JY:  The molecular basis of glycogen storage disease type 1a: structural and functional analysis of mutants in glucose-6-phosphatase. J Biol Chem 2002; 277: 5047-5053. 
  • Shieh JJ, Liang CM, Chen CY, Lee F, Jong MH, Lai SS, Liang SM: Enhancement of the immunity to foot-and-mouth disease virus by DNA priming and protein boosting immunization. Vaccine 2001; 19: 4002-4010. 
  • Shieh JJ, Lin CY:  A frequent mutation in Chinese patients with infantile type of GSD II in Taiwan: Evidence for a founder effect. Hum Mutat 1998; 11:306-312. 
  • Shieh JJ, Lin CY:  Identification of a small deletion in one allele of patients with infantile form of glycogen storage disease type II. Bioche Biophy Res Commu 1996; 219: 322-326. 
  • Lin CY, Shieh JJ:  Molecular study on the infantile form of Pompe disease in Chinese in Taiwan. Acta Paed Sin 1996; 37:115-121.
  • Lin CY, Shieh JJ:  Identification of a de novo point mutation resulting in infantile form of Pompe’s disease. Bioche Biophy Res Commu 1995; 208:886-893. 
  • Shieh JJ, Wang LY, Lin CY:  Point mutation in Pompe disease in Chinese. J Inher Metab Disease 1994; 17:145-148. 

研討會論文

  • Li, Z.Y., Shieh, J.J., Imiquimod-induced senescence was mediated by increasing K382 acetylation of p53 through Sirt1 downregulation in skin cancer cells. In: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology, Hotel Aomori, Aomori, Japan, November 8-10, 2019.
  • Chuang, K.C., Shieh, J.J., Imiquimod disrupts mitochondrial dynamic balance and leads to mitophagy. In: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology, Hotel Aomori, Aomori, Japan, November 8-10, 2019.
  • Chang, S.H., Wu, C.Y., Shieh, J.J., Lysosome adaption compensated imiquimod-induced cell death in skin cancer cells. In: The 44th Annual Meeting of the Japanese Society for Investigative Dermatology, Hotel Aomori, Aomori, Japan, November 8-10, 2019.
  • Chang, S.H., Huang, S.W., Cheng, C.C., Wu, C.Y., Shieh, J.J. Enhancement of lysosomal function contributes to imiquimod-acquired resistance in skin cancer cells. In: 2019 24th World Congress of Dermatology, Milan, Italy, June 10-15, 2019.
  • Chang, S.H., Shieh, J.J., Imiquimod induces ER stress and PKR-mediated autophagy via ROS production in cancer cells. In: Frontiers in Cancer Science 2015. Singapore, November 2-4, 2015.
  • Wang, S.T., Shieh, J.J., Wu, C.Y., Statins inhibit hepatocellular carcinoma progression: population-based and in vitro studies. In: Frontiers in Cancer Science 2015. Singapore, November 2-4, 2015.
  • Huang, S.W., Wang, S.T., Wu, C.Y., Chen, Y.J., Shieh, J.J., Imiquimod activates p53-dependent apoptosis in human skin cancer cells. In: Frontiers in Cancer Science 2015. Singapore, November 2-4, 2015.
  • Huang, S.W., Shieh, J.J., The antibiotic azithromycin improves the severity with imiquimod-induced psoriasis like skin inflammation in mice. In: 39th Annual Meeting of the Japanese Society for Investigative Dermatology. Osaka, Japan, December 12-14, 2014.
  • Wang, S.T., Shieh, J.J., Huang, S.W., Wu, C.Y., IMQ induced AMPK activation causes translation inhibition and apoptosis but not autophagy. In: 39th Annual Meeting of the Japanese Society for Investigative Dermatology. Osaka, Japan, December 12-14, 2014.
  • Chang, S. H., Shieh, J.J., Huang, S.W., Imiquimod induces STAT3-mediated autophagy via ROS production in cancer cells.  In: 39th Annual Meeting of the Japanese Society for Investigative Dermatology. Osaka, Japan, December 12-14, 2014.
  • Shieh, J.J., Huang, S.W., Imiquimod Induces HIF-1lpha Expression and Aerobic Glycolysis to Protect Imiquimod-induced Apoptosis in Cancer Cells. In: The 6th Annual Asian Oncology Summit (AOS) and 10th Annual Conference of the Organisation for Oncology and Translational Research (OOTR), Kuala Lumpur, Malaysia, April 11-13, 2014.
  • Chen, Y.J., Huang S.W., Wang, S.T., Cheng, H.Y., Shieh, J.J., Azithromycin improves imiquimod-induced psoriasis-like skin inflammation. In: The 8th International Congress on Cutaneous Adverse Drug Reactions and The 39th Annual Meeting of the Taiwanese Dermatological Association, Chang-Gung University, Taiwan, November 16-17, 2013.
  • Huang, S.W., Chen, Y.J., Cheng, H.Y., Wang, S.T., Shieh, J.J., Antibiotic Azithromycin improves the severity of mice with imiquimod-induced psoriasis like skin inflammation. In: 2013 Asia Pacific Congress of Allergy, Asthma and Clinical Immunology. Taipei, Taiwan, November 14-17, 2013.
  • Shieh, J.J., Huang, S.W., The glucose availability and the induction of HIF-1 alpha expression determine the imiquimod induced apoptosis in cancer cells. In: 37th Annual Meeting of the Japanese Society for Investigative Dermatology. Okinawa, Japan, December, 7-9, 2012.
  • Shieh, J.J., Huang, S.W., Mu, S.W., Chen, Y.Y. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. In: 36th Annual Meeting of the Japanese Society for Investigative Dermatology. Kyoto, Japan, December, 9-11, 2011.
  • Huang, S.W., Shieh, J.J. Mcl-1 over-expression causes resistance to imiquimod-induced apoptosis but not imiquimod-induced autophagy in basal cell carcinoma cells. In 22nd World Congress of Dermatology. Seoul, Korea, May, 24-29, 2011. (Silver Award of E. Poster) 
  • Huang, S.W., Liu, K.T., Shieh, J.J. The Interplay between Imiquimod Induced Autophagy and Apoptosis in Human Basal Cell Carcinoma Cells. In: 34th Annual Meeting of the Japanese Society for Investigative Dermatology. Fukuoka, Japan, December, 4-6, 2009.
  • Shieh, J.J., Chen, C.T., Huang, W.R. The variant glucose-6-phosphate transporter decreases protein stability and requires MyoD-dependent alternative splicing during myogenesis of muscle cells. Experimental Biology 2007 Annual Meeting. Washington D.C., USA, April 28-May 2, 2007.
  • Shieh, J.J., Lin, C.Y. Identification of novel splicing variants of the human Na+/Pi cotransporter 4 in human kidney. Experimental Biology 2005 Annual Meeting and the XXXV International Congress of Physiological Sciences. San Diego, California, USA, April 2-6, 2005.
  • Shieh, J.J., Terzioglu, M., Pan, C.J., Chen, L.Y., Hirawa, H., Chou, J.Y. The Molecular basis of glycogen storage disease type 1a: structural and functional analysis of mutations in glucose-6-phosphatase. The 51st Annual Meeting of the American Society of Human Genetics. San Diego, California, USA, October 12-16, 2001.
  • Shieh, J.J., Liang, C.M., Wang, J.H., Kao, K., Chen, C.Y., Yang, N.S., Liang, S.M.  Immune responses induced by FMDV VP1 DNA priming and protein boosting. 1999 Winter Biotechnology Conference at Cold Spring Harbor Meeting on Molecular Approaches to Vaccine Design. Cold Spring Harbor, New York, USA, December 2-5, 1999.
  • Shieh, J.J., Lin, C.Y.  Frequent mutation in Chinese patients with infantile type of GSD II in Taiwan: evidence for a founder effect. Acid Maltase Deficiency Association Conference. San Antonio, Texas, USA, June 23-25, 1997.
  • Shieh, J.J., Lin, C.Y.  Molecular study of Pompe’s disease in Chinese. The 6th   International Congress of Inborn Errors of Metabolism. Milano, Italy, May 27-31, 1994.

專利及技轉 

  • Liang SM, Wang JH, Shieh JJ (2007): VP1 of foot-and-mouth disease virus. (US patent 7,217,784).
  • Liang SM, Wang JH, Shieh JJ (2007): 口蹄疫病毒之VP1蛋白質 (中華民國專利 I-285111號) 
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