移至主內容

許美鈴

許美鈴
特聘教授
台灣大學醫學院毒理學博士
台中榮總研究大樓R202/分子毒理實驗室
(04)23592525#4402
mlsheu@nchu.edu.tw

研究領域

  1. 分子毒理學及免疫毒理學
  2. 代謝及血管生物醫學
  3. 內質網壓力於胃腸發炎癌變暨腹膜轉移-胃癌,大腸癌
  4. 糖尿病糖化終產物代謝及血管生物醫學-大小血管病變
  5. 天然藥物與新化合藥物開發於動物毒性測試與影像分析

教授科目

上學期-毒理學(2學分)

上學期-毒性物與受器交互作用學(2學分)

上學期-生物技術特論暨生物技術學實驗(一)(3學分)

上學期-訊息傳遞與人類疾病特論(一)(2學分)

上學期-自由基及氧化壓力學(2學分)

下學期-分子毒理學(2學分)

下學期-環境毒理學(2學分)

下學期-生物技術特論暨生物技術學實驗(二)(3學分)

下學期-訊息傳遞與人類疾病特論(二)(2學分)

下學期-內質網壓力學(2學分)

全學年-高等血管新生學暨實驗(6學分)

全學年-一氧化氮生物學特論(4學分)

【大學部】下學期-毒理學概論(3學分)

簡要經歷

主任            2023/08-2024/07     生技產業創新研發與管理博士學位學程/生科院

主任            2023/08-2024/07     榮興轉譯醫學研究中心

主任            2023/02-2023/07     生醫產業研發中心/生科院

副主任          2022/08-2023/07     榮興轉譯醫學研究中心

終身特聘教授    2022/08-迄今        中興大學生物醫學研究所

特聘教授        2018/08-2024/07     中興大學生物醫學研究所

所長            2019/08-2022/07     中興大學生物醫學研究所

教授            2014/02-迄今        中興大學生物醫學研究所

副教授          2011/02-2014/01     中興大學生物醫學研究所

助理教授        2009/08-2011/01     中興大學生科院生物醫學研究所

助理教授        2007/02-2009/07     中興大學生科院醫學科技研究所

助理教授        2005/08-2007/01     中山醫學大學醫學檢驗學系

博士後研究員    2005/02-2005/07     台灣大學醫學院

博士            2000/09-2005/02     台灣大學醫學院毒理學研究所

研究助理        1999/08-2000/07     台北榮總癌症中心

碩士            1997/09-1999/06     陽明大學解剖暨細胞生物研究所

國中教師        1993/07-1997/07     高雄市立楠梓國中生物教師

學士            1990/09-1993/06     中山醫學大學醫學檢驗學系

獲獎項目

  

獲獎項目

2023/10 黃振庭同學參加第38屆天然藥物研討會榮獲-薪萌獎

2023/07 指導周健朗同學參加第10屆亞洲毒理學國際大會(ASIATOX-X) 壁報論文競賽榮獲-卓越傑出海報獎

2023/03 黃振庭同學參與第37屆生物醫學聯合學術年會台灣毒物學會壁報論文競賽榮獲2023年永信李天德醫藥基金會壁報論文獎-優等獎

2023/03 指導周健朗同學參加37屆生物醫學聯合學術年會中華民國毒物學學會壁報論文競賽榮獲-第一名

國軍退除役官兵輔導委員會台中榮總110年度研究發展―特優獎

2022/03 曾畹庭同學參與第36屆生物醫學聯合學術年會中華民國生理學學會壁報論文競賽榮獲2022年永信李天德醫藥基金會壁報論文獎-特優獎

2022/03 張愛同學參與第36屆生物醫學聯合學術年會中華民國細胞及分子生物學學會壁報論文競賽榮獲2022年永信李天德醫藥基金會壁報論文獎-優等獎

2022/03 吳昇懋博士獲選第36屆生醫年會大會主題競賽-第二名

2022/03 吳昇懋博士獲選110年度杜聰明博士研究生論文獎-佳作

2022/03 邢相媛獲選第十七屆中華民國解剖學學會碩博士研究生學術論文競賽碩士組-第二名

2022/03 獲選第36屆生物醫學聯合學術年會台灣毒物學學會壁報論文競賽-佳作

2022/03 李芸萱獲選第36屆生物醫學聯合學術年會台灣毒物學學會口頭論文競賽-第三名

20202/01指導李芸萱同學參加2022第28屆細胞及分子生物新知研討會,榮獲-優秀壁報論文獎

20201/12指導張愛同學參加2021全國生物科技暨健康產業國際學術研討會B組海報論文競賽,榮獲-第二名

20201/12指導李芸萱同學參加2021全國生物科技暨健康產業國際學術研討會B組海報論文競賽榮獲-第三名

20201/11傅國翔同學中興大學生科院獎學金

20201/11同學中興大學生科院獎學金

20201/11王思婷同學中興大學生科院獎學金

20201/11李芸萱同學中興大學生科院獎學金

2021/12吳昇懋博士後研究員榮獲110年年輕學者創新研發成果選拔博士後研究員及博士級研究生組榮獲-佳作獎

2021/10指導張愷峻同學參加36屆天然藥物研討會及藥學暨中醫藥學門成果發表會榮獲壁報論文競賽-第三名

2021/10指導傅國翔同學參加36屆天然藥物研討會及藥學暨中醫藥學門成果發表會榮獲壁報論文競賽-佳作

2021/10指導傅國翔同學參加2021台灣生化學會秋令營研討會,榮獲壁報論文競賽-佳作

2021/10指導張愷峻同學參加2021台灣生化學會秋令營研討會,榮獲壁報論文競賽-壁報人氣獎

2021/10指導王思婷同學參加2021台灣生化學會秋令營研討會,榮獲壁報論文競賽-佳作

2021/10指導李芸萱同學參加2021台灣生化學會秋令營研討會,榮獲壁報論文競賽-佳作

2021/10指導邢相媛同學參加2021台灣生化學會秋令營研討會,榮獲壁報論文競賽-佳作

2021/01指導邢相媛同學參加2020全國三分鐘生科論文口說競賽中區初賽榮獲優勝

2020/11指導華盛頓中學三年級彭柏叡同學參加中央研究院109學年度高中生命科學研究人才培育計畫壁報論文-甲等獎

2020「108年度台中榮總與中區各大學院校合作研究計畫聯合成果發表會壁報報告」-特優

2020指導大學部生技學程曾子瑄同學榮獲2020年中興大學理學院科技論文競賽-生物領域-佳作

2020指導生科系大學部王信傑同學榮獲2020年中興大學理學院科技論文競賽-生物領域-第一名

2019指導生科系大學部王信傑同學榮獲2019年台灣生化學會秋令營研討會壁報論文競賽-佳作

2019指導生科系大學部王信傑同學榮獲台灣基因體暨遺傳學會2019年轉譯醫學學術研討會暨學術論文競賽壁報論文競賽-佳作

2019「107年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽-第一名

2019指導吳昇懋同學榮獲第16屆中華民國解剖學學會碩博士研究生學術論文競賽博士組-第二名

2019指導歐蕙葶同學榮獲第16屆中華民國解剖學學會碩博士研究生學術論文競賽碩士組-第三名

2019指導邢相媛同學榮獲第24屆台灣癌症聯合學術年會壁報論文競賽『基礎轉譯組』佳作

2019指導吳昇懋同學榮獲第34屆生物醫學聯合學術年會中華民國毒物學學會口頭論文競賽榮獲第一名

2019指導邢相媛同學榮獲第16屆中華民國解剖學學碩博士研究生學術論文競賽碩士組-佳作

2019指導吳昇懋同學榮獲第一屆台灣毒理學學會墾丁冬令營英文口頭論文競賽–第三名

2019指導邢相媛同學榮獲第一屆台灣毒理學學會墾丁冬令營英文口頭論文競賽–佳作

2019指導歐蕙葶同學榮獲第一屆台灣毒理學學會墾丁冬令營海報論文競賽–佳作

2018指導張育瑄同學榮獲中國材料科學學會海報論文競賽–特優

2018指導張育瑄同學榮獲台灣化學工程學會65周年年會暨科技部化學工程學門成果發表會壁報論文競賽-佳作

2018指導張育瑄同學榮獲中華民國尖端材料科技學會論文比賽-特優

2018指導歐蕙葶同學榮獲2018中華實驗動物學會第十五屆第二次會員大會暨學術研討會-壁報論文第四名

2018指導邢相媛同學榮獲台灣基因體暨遺傳學會2018年轉譯醫學學術研討會暨學術論文競賽-口頭報告第三名

2018指導賴德偉同學參加14屆永信李天德醫藥科技獎,榮獲:傑出論文獎

2018「106年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽第一名

2018指導謝宜真同學榮獲第23屆台灣癌症聯合學術年會壁報論文競賽『基礎轉譯組』第八名

2018指導林聖涵同學榮獲第23屆台灣癌症聯合學術年會壁報論文競賽『基礎轉譯組』佳作

2018指導林聖涵同學榮獲第15屆中華民國解剖學學碩博士研究生學術論文競賽碩士組-第一名

2018指導沈軒宇同學榮獲獎第15屆中華民國解剖學學碩博士研究生學術論文競賽碩士組-佳作

2018指導呂庭宇同學榮獲第33屆生物醫學聯合學術年會台灣生物化學及分子生物學學會壁報論文競賽-佳作

2018指導賴德偉同學榮獲中華民國內分泌暨糖尿病學會第十三屆第三次會員大會暨學術研討會壁報比賽第一名

2017指導賴德偉同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-口頭報告第一名

2017指導謝宜真同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-口頭報告優秀獎

2017指導呂庭宇同學榮獲2017年台灣生化學會秋令營研討會壁報論文競賽-佳作

2017指導林聖涵同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-壁報比賽優秀獎

2017指導吳昇懋同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-壁報比賽優秀獎

2017指導沈軒宇同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-壁報比賽優秀獎

2017指導賴德偉同學榮獲2017第14屆林榮耀教授學術教育基金會論文獎

2017指導吳昇懋同學榮獲2017第14屆林榮耀教授學術教育基金會論文獎

國軍退除役官兵輔導委員會台中榮總105年度研究發展―特優獎

2017指導賴德偉同學參加32屆生物醫學聯合學術年會中華民國毒物學學會口頭論文競賽榮獲第一名

2017指導賴德偉同學參加32屆生物醫學聯合學術年會台灣生化學會研究生壁報論文競賽榮獲優秀壁報論文獎

2017指導盧柏超同學參加15屆中華民國解剖學學會碩博士研究生壁報論文競賽-碩士組第一名

2017指導賴德偉同學參加15屆中華民國解剖學學會碩博士研究生壁報論文競賽-博士組第二名

2017指導賴德偉同學參加22屆台灣癌症聯合學術年會壁報論文競賽『基礎轉譯組』第七名

2016指導吳昇懋同學參加12屆永信李天德醫藥科技獎,榮獲-傑出論文獎

2016指導盧柏超同學參加台灣基因體暨遺傳學會2016年轉譯醫學學術研討會暨學術論文競賽壁報比賽優秀獎

2016指導沈軒宇同學參加台灣基因體暨遺傳學會2016年轉譯醫學學術研討會暨學術論文競賽壁報比賽優秀獎

2016指導吳昇懋同學參加第30屆天然藥物研討會藥學暨中醫藥學門成果發表會―壁報論文優秀獎藥理組第二名

2016指導碩士班研究生湯舒晴同學參加生醫年會解剖學會的學術論文競賽-佳作

2016指導博士班研究生吳昇懋同學參加中華民國細胞及分子生物學會榮獲徐千田優秀論文獎

2015指導碩士班研究生湯舒晴同學參加台灣生化學會秋令營研討會優秀壁報論文獎

2015指導碩士班研究生張以潔同學參加台灣生化學會秋令營研討會優秀壁報論文獎

國軍退除役官兵輔導委員會台中榮總103年度研究發展特優獎

2015台中榮總與中區各大學合作研究計劃聯合成果發表論文競賽優良論文

2015「103年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽第一名

2015指導博士班研究生賴德偉同學參加第二十九屆生物醫學聯合學術年會中華民國毒物學學會論文壁報競賽榮獲佳作

2015指導碩士班研究生劉珈妤同學參加第二十九屆生物醫學聯合學術年會中華民國毒物學學會口頭論文競賽榮獲佳作

2014指導碩士班研究生劉珈妤同學參加103年台灣基因醫學暨生物標記學會論文壁報競賽榮獲金質獎

2014實驗室獲選―「基因醫學教育推廣優秀單位」

2014指導碩士班研究生劉珈妤同學參加103年台灣基因醫學暨生物標記學會「第二屆全國基因廣角鏡徵文比賽」銅質獎

2014指導中興大學生科系蔡宗志同學參加第十四屆中華民國解剖學學會大學組學術論文競賽第一名

2014指導中興大學生科系蔡宗志同學參加生科院學士研究成果壁報競賽特優獎

2014第六屆亞太拜耳華人糖尿病論壇―ABCD最佳基礎研究獎

2014指導碩士班研究生劉珈妤同學參加第十三屆中華民國解剖學學會碩士班學術論文競賽第二名

103年度「國立中興大學優秀年輕學者獎助計畫(懷璧獎)」生命科學組

2013指導碩士班研究生劉珈妤同學參加2013年的台灣生物化學及分子生物學學會冬令營榮獲碩士班組口頭論文競賽第一名

2013指導博士班研究生賴德偉同學參加2013年的台灣生物化學及分子生物學學會冬令營榮獲博士班組壁報論文獎佳作

2013指導博士班研究生賴德偉同學參加「102年台灣基因醫學暨生物標記學會年會暨基因醫學臨床應用研討會」論文競賽榮獲―「普生優秀論文銅質獎」

2013實驗室獲選「基因醫學教育推廣優秀單位」

2013指導碩士班研究生賴德偉同學參加第28屆生物醫學年會毒理學會-口頭競賽第二名

2013指導碩士班研究生賴德偉同學參加2013台灣蛋白體年會暨國際轉譯醫學新知研討會壁報論文獎佳作

2013共同指導助理蔡怡青小姐參加「101年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」口頭論文競賽第一名

2013共同指導助理蔡怡青小姐參加「101年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽第一名

2013共同指導助理陳霈萱小姐參加「101年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽第二名

2013指導碩士班研究生賴德偉同學參加2013生物醫學研究所碩士班口頭論文競賽第一名

2013參加第五屆亞太拜耳華人糖尿病論壇ABCD最佳口頭報告一等獎

2013指導助理田幸茹小姐參加台灣基因醫學暨生物標記學會比賽特別獎

2013指導助理蔡怡青小姐參加台灣基因醫學暨生物標記學會比賽特別獎

2013指導碩士班研究生賴德偉同學參加2013年的台灣生物化學及分子生物學學會惠蓀林場冬令營榮獲口頭論文競賽第二名

2013指導碩士班研究生賴德偉同學參加2013年的生物醫學年會台灣生物化學及分子生物學學會海報論文競賽優等

2012指導助理田幸茹小姐參加「100年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」論文競賽第一名

2012指導碩士班研究生吳昇懋同學參加101年台灣基因醫學暨生物標記學會/基因標記暨轉譯醫學應用研討會壁報論文競賽第二名

2012指導碩士班研究生陳怡靜同學參加中華民國解剖學學會第12屆壁報論文競賽第一名

2012指導碩士班研究生蔡怡青同學參加第27屆生物醫學年會毒理學會口頭競賽第二名

2012指導碩士班研究生陳怡靜同學參加2012生物醫學研究所碩士班口頭論文競賽第一名

2012指導碩士班研究生吳昇懋同學參加2012生物醫學研究所碩士班口頭論文競賽第二名

2012指導碩士班研究生蔡怡青同學參加2012生物醫學研究所碩士班口頭論文競賽第四名

2012指導碩士班研究生吳昇懋同學參加2012轉譯醫學之基因體與蛋白質體之臨床應用學術研討會壁報論文比賽佳作

2012指導助理田幸茹小姐參加2012轉譯醫學之基因體與蛋白質體之臨床應用學術研討會壁報論文比賽第二名

2010指導助理田幸茹小姐參加台中榮民總醫院與中興大學合作研究計畫聯合研究成果發表壁報論文競賽第一名

2009台中榮民總醫院與中興大學合作研究計畫聯合研究成果發表壁報論文競賽第三名

2009指導碩士班研究生王致堅同學參加二十四屆生物醫學聯合學術年會議毒物學學會優秀學術壁報論文獎

2009指導研究生王致堅同學參加九十八年基因體與蛋白質體學術研討會壁報比賽第一名

2007第二十二屆生物醫學聯合學術會議毒物學學會優秀學術論文獎作獎

2006中山醫學大學教師學術研究著作論文獎

2006財團法人杏園基金會學術論文獎

2005台灣大學醫學院研究生優秀著作獎優等獎

2005台灣大學醫學院研究生論文優秀獎學金

2004第十九屆生物醫學聯合學術會議毒理學會優秀論文選拔第一名

2003中華民國毒理學學會第一屆春令營論文競賽第二名

1999陽明大學學術論文競賽壁報展第五名

1999陽明醫學教育基金會獎學金

1999紀念尹珣若先生品學及論文優秀獎學金

1999中華民國解剖學學會研究生論文競賽第一名

 

  

學術著作

  1. Melatonin enhanced microglia M2 polarization in rat model of Neuro-inflammation via regulating ER Stress/PPARd/SIRT1 signaling axis. Pan HC, Yang CN, Lee WJ, Sheehan J, Wu SM, Chen HS, Lin MH, Shen LW, Lee SH, Shen CC, Pan LY, Liu SH, Sheu ML*. Journal of Neuroimmune Pharmacology IF: 7.289 PHARMACOLOGY & PHARMACY 27/279=9.6%, 2022JCR
  2. Ne-(1-Carboxymethyl)-L-lysine/RAGE Signaling Drives Metastasis and Cancer Stemness through ERK/NFκB axis in Osteosarcoma. Chang TY, Lan KC, Wu CH, Sheu ML*, Yang RS*, Liu SH*. International Journal of Biological Sciences. 2024 Jan 12;20(3):880-89
  3. Neuronal Death Caused by HMGB1-Evoked via Inflammasomes from Thrombin-Activated Microglia Cells. Sheu ML, Pan LY, Yang CN, Sheehan J, Pan LY, You WC, Wang CC, Chen HS, Pan HC. International Journal of Molecular Sciences. 2023 Aug 11;24(16):12664.
  4. TPL2 aids gastric cancer cell proliferation and chemoresistance through intensifying hypoxia/PPARd axis. Lan KL, De-Wei Lai DW, Yang CN, Pan HC, Ou HT, Huang ZT, Chou KL, Wu SM, Shen LW, Shen CC, Chen L, Liu SH, Chiu CS, Arbiser JL and Sheu ML*. British Journal of Pharmacology IF: 7.3 PHARMACOLOGY & PHARMACY 24/278=8.63%, 2022JCR
  5. Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer. Wu SM, Jan YJ, Pan HC, Shen CC, Yang CN, Lee SH, Liu SH, Shen LW, Chiu CS, Arbiser JL, Meng M, Sheu ML*CELL BIOLOGY AND TOXICOLOGY. 2023 Oct;39(5):1873-1896. Impact Factor: 6.691, TOXICOLOGY 6/93= 6.4%, 2020JCR110年年輕學者創新研發成果選拔博士後研究員及博士級研究生組,榮獲-佳作獎】獲選110年度杜聰明博士研究生論文獎-佳作】
  6. Thrombin-Induced Microglia Activation Modulated through Aryl Hydrocarbon Receptors. Sheu ML, Pan LY, Yang CN, Sheehan J, Pan LY, You WC, Wang CC, Pan HC. International Journal of Molecular Sciences. 2023 Jul 13;24(14):11416.
  7. Nε-(1-Carboxymethyl)-L-lysine, an advanced glycation end product, exerts malignancy on chondrosarcoma via the activation of cancer stemness. Chang TY, Lan KC, Wu CH, Sheu ML*, Yang RS, Liu SH. Archives of Toxicology. 2023 Aug;97(8):2231-2244.

  8. Melatonin protects retinal integrity through mediated immune homeostasis in the sodium iodate-induced mouse model of age-related macular degeneration. Ku LC, Sheu ML, Cheng HH, Lee CY, Tsai YC, Tsai CY, Lin KH, Lai LC, Lai DW. Biomedicine & Pharmacotherapy. 2023 May;161:114476.

  9. Using the deformity index of vital structures to predict outcome of patients with large vestibular schwannomas after Gamma Knife radiosurgery. Chang HC, You WC, Shen CC, Chen YJ, Sun MH, Sheu ML, Pan LY, Sheehan J, Su KC, Pan HC. Journal of Neuro-Oncology. 2023 Mar;162(1):179-189.

  10. Potential Therapeutic Effects of Thiazolidinedione on Malignant Glioma. Sheu ML, Pan LY, Hu HY, Su HL, Sheehan J, Tsou HK, Pan HC. International Journal of Molecular Sciences. 2022 Nov 4;23(21):13510.

  11. AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression. Cheng HH, Hung-Ke L, Sheu ML, Lee CY, Tsai YC, Lai DW. Immunology. 2023 Apr;168(4):654-670.

  12. Influence of COVID-19 pandemic on the decision making of patients in undergoing gamma knife radiosurgery. Shen CC, Jiang RS, Yang MY, You WC, Sun MH, Sheu ML, Pan LY, Sheehan J, Pan HC. European Journal of Medical Research. 2022 Oct 29;27(1):223.

  13. Modulation of Aryl Hydrocarbon Receptor Expression Alleviated Neuropathic Pain in a Chronic Constriction Nerve Injury Animal Model. Sheu ML, Pan LY, Sheehan J, Yang MY, Pan HC. International Journal of Molecular Sciences. 2022 Sep 24;23(19):11255.

  14. Aryl hydrocarbon receptor deficiency augments dysregulated microangiogenesis and diabetic retinopathy. Lee WJ, Lin KH, Wang JS, Sheu WH, Shen CC, Yang CN, Wu SM, Shen LW, Lee SH, Lai DW, Lan KL, Tung CW, Liu SH, Sheu ML*. BIOMEDICINE & PHARMACOTHERAPY. 2022 Sep 21;155:113725. IF: 7.419 PHARMACOLOGY & PHARMACY 26/279=9.3%, 2021JCR

  15. Modulation of Aryl Hydrocarbon Receptor Expression Alleviated Neuropathic Pain in a Chronic Constriction Nerve Injury Animal Model Sheu ML, Pan LY, Sheehan Jason, Yang MY and Pan HC. International Journal of Molecular Sciences. 2022, 23, 11255.

  16. Gamma Knife Radiosurgery for Indirect Dural Carotid-Cavernous Fistula: Long-Term Ophthalmological Outcome. Shen CC, Tsuei YS, Yang MY, You WC, Sun MH, Sheu ML*, Pan LY, Sheehan J, Pan HC. Life (Basel). 2022 Aug 1;12(8):1175.

  17. Ameliorative Potential of Hot Compress on Sciatic Nerve Pain in Chronic Constriction Injury-Induced Rat Model. Chan KY, Tsai WC, Chiang CY, Sheu MLHuang CY, Tsai YC, Tsai CY, Lu CJ, Ho ZP, Lai DW. Frontiers in Synaptic Neuroscience. 2022 May 24;14:859278.

  18. ANGPTL1 attenuates cancer migration, invasion, and stemness through regulating FOXO3a-mediated SOX2 expression in colorectal cancer. Chang TY, Lan KC, Chiu CY, Sheu ML*, Liu SH. CLINICAL SCIENCE (Lond). 2022 May 13;136(9):657-673. 

  19. Aggravation of pulmonary fibrosis after knocking down the Aryl hydrocarbon receptor in the Insulin-like growth factor 1 receptor pathway. Wu SM, Tsai JJ, Pan HC, Arbiser JL, Elia L, Sheu ML*, British Journal of Pharmacology 2022 Jul;179(13):3430-3451. Impact Factor: 8.740, PHARMACOLOGY & PHARMACY12/276= 4.3%, 2020JCR 【獲選第36屆生醫年會大會主題競賽-第二名】

  20. Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer. Wu SM, Jan YJ, Pan HC, Shen CC, Yang CN, Lee SH, Liu SH, Shen LW, Chiu CS, Arbiser JL, Meng M, Sheu ML*CELL BIOLOGY AND TOXICOLOGY. 2023 Oct;39(5):1873-1896. Impact Factor: 6.691, TOXICOLOGY 6/93= 6.4%, 2020JCR110年年輕學者創新研發成果選拔博士後研究員及博士級研究生組,榮獲-佳作獎】獲選110年度杜聰明博士研究生論文獎-佳作】

  21. Attenuation of in vitro and in vivo melanin synthesis using a Chinese herbal medicine through the inhibition of tyrosinase activity. Liu SC, Sheu ML, Tsai YC, Lin YC, Chang CW, Lai DW. Phytomedicine. 2022 Jan;95:153876.

  22. CARMA3 Promotes Colorectal Cancer Cell Motility and Cancer Stemness via YAP-Mediated NF-κB Activation. Chang TY, Wu CT, Sheu ML*, Yang RS, Liu SH. Cancers (Basel). 2021 Nov 26;13(23):5946.

  23. Outcome of intracerebral cavernoma treated by Gamma Knife radiosurgery based on a double-blind assessment of treatment indication. Shen CC, Sun MH, Yang MY, You WC, Sheu ML, Chen YJ, Chen YJ, Sheehan J, Pan HC. Radiation Oncology. 2021 Aug 28;16(1):164.

  24. Advanced glycation end products activated endothelial-to-mesenchymal transition in pancreatic islet endothelial cells and triggered islet fibrosis in diabetic mice. Tsai PS, Chiu CY, Sheu ML, Yang CY, Lan KC, Liu SH. CHEMICO-BIOLOGICAL INTERACTIONS. 2021 Aug 25;345:109562.

  25. Dual Regeneration of Muscle and Nerve by Intramuscular Infusion of Mitochondria in a Nerve Crush Injury Model. Sheu ML, Shen CC, Tsou HK, Yang MY, Su HL, Sheehan J, Chang MH, Chen HS, Pan HC. NEUROSURGERY. 2021 Jun 15;89(1):E49-E59.

  26. Therapeutic Potential of Tpl2 (Tumor Progression Locus 2) Inhibition on Diabetic Vasculopathy Through the Blockage of the Inflammasome Complex. Sheu WH, Lin KH, Wang JS, Lai DW, Lee WJ, Lin FY, Chen PH, Chen CH, Yeh HY, Wu SM, Shen CC, Lee MR, Liu SH, Sheu ML*ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021 Jan;41(1):e46-e62. Impact Factor: 8.313, PERIPHERAL VASCULAR DISEASE 5/65= 7.69%, 2020JCR

  27. Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury. Huang KH, Guan SS, Lin WH, Wu CT, Sheu ML, Chiang CK, Liu SH. Cells. 2019 Jun 30;8(7):660.

  28. Increased angiogenesis by the rotational muscle flap is crucial for nerve regeneration. Pan HC, Chang MH, Sheu ML, Chen CJ, Sheehan J. PLoS One. 2019 Jun 10;14(6):e0217402.
  29. Novel electrospun poly(ε-caprolactone)/type I collagen nanofiber conduits for repair of peripheral nerve injury. Yen CM, Shen CC, Yang YC, Liu BS, Lee HT, Sheu ML, Tsai MH, Cheng WY. Neural Regeneration Research. 2019 Sep;14(9):1617-1625.
  30. The association between infection incidence and autoimmune diseases in breast cancer patients after anti-cancer treatment. Chen CC, Ho WL, Chen HH, Sheu ML, Hsu CY, Chen JP. Journal of Cancer. 2019 Jan 29;10(4):829-835.
  31. Exploiting Honokiol-induced ER stress CHOP activation inhibits the growth and metastasis of melanoma by suppressing the MITF and β-catenin pathways. Chiu CS, Tsai CH, Hsieh MS , Tsai SC, Jan YJ, Lin WY, Lai DW, Wu SM, Hsing HY, Arbiser JL, Sheu ML*Cancer Letters. 2019 Feb 1;442:113-125.  Impact Factor: 6.491, ONCOLOGY 29/223= 13%, 2017JCR
  32. Novel Combination of Arsenic Trioxide (As2O3) Plus Resveratrol in Inducing Programmed Cell Death of Human Neuroblastoma SK-N-SH Cells. Yen CM, Tsai CW, Chang WS, Yang YC, Hung YW, Lee HT, Shen CC, Sheu ML, Wang JY, Gong CL, Cheng WY, Bau DT. Cancer Genomics & Proteomics. 2018 Nov-Dec;15(6):453-460.
  33. Intrathecal Injection of Dual Zipper Kinase shRNA Alleviating the Neuropathic Pain in a Chronic Constrictive Nerve Injury Model. Sheu ML, Chiang CY, Su HL, Chen CJ, Sheehan J, Pan HC. Int J Mol Sci. 2018 Aug 16;19(8):2421.
  34. Outcome of partially irradiated recurrent nonfunctioning pituitary macroadenoma by gamma knife radiosurgery. Shen CC, You WC, Sun MH, Lee SD, Tsou HK, Chen YJ, Sheu ML, Sheehan J, Pan HC. JOURNAL OF NEURO-ONCOLOGY. 2018 Sep;139(3):767-775.
  35. Late administration of high-frequency electrical stimulation increases nerve regeneration without aggravating neuropathic pain in a nerve crush injury. Su HL, Chiang CY, Lu ZH, Cheng FC, Chen CJ, Sheu ML, Sheehan J, Pan HC. BMC NEUROSCIENCE. 2018 Jun 25;19(1):37.
  36. Down-Regulated Expression of Magnesium Transporter Genes Following a High Magnesium Diet Attenuates Sciatic Nerve Crush Injury. Chen YJ, Cheng FC, Chen CJ, Su HL, Sheu ML, Sheehan J, Pan HC. NEUROSURGERY. 2019 Apr 1;84(4):965-976.
  37. Outcome of hearing preservation related to tumor morphologic analysis in acoustic neuromas treated by gamma knife radiosurgery. Pan SY, Liu SA, Sun MH, Tsou HK, Lee SD, Chen YJ, Sheehan J, Sheu ML, Pan HC. Radiation Oncology. 2017 Aug 15;12(1):134.  
  38. Therapeutic Targeting Tumor Progression Locus-2 (TPL2)/Activating Transcription Factor-4 (ATF4)/Chemokine Stromal Cell-Derived Factor-α (SDF1α) Axis Suppresses Diabetic Retinopathy. Lai DW, Lin KH, Sheu WH, Lee MR, Chen CY, Lee WJ, Hung YW, Shen CC, Chung TJ, Liu SHSheu ML*. Circulation Research. 2017 Sep 1;121(6):e37-e52. Impact Factor: 13.965, HEMATOLOGY 1/70= 1.42%, 2016JCR 【研究生獲選-201714屆林榮耀教授學術教育基金會論文獎】【第14屆永信李天德醫藥科技獎,研究生獲選-傑出論文獎】
  39. Prevention of Axonal Degeneration by Perineurium Injection of Mitochondria in a Sciatic Nerve Crush Injury Model. Kuo CC, Su HL, Chang TL, Chiang CY, Sheu ML, Cheng FC, Chen CJ, Sheehan J, Pan HC. Neurosurgery. 2017 Mar 1;80(3):475-488.
  40. Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation. Sheu ML, Shen CC, Jheng JR, Chiang CK. Oncotarget. 2017 Mar 7;8(10):16925-16938. Impact Factor: 5.168, ONCOLOGY 44/127= 20.29%, 2016JCR
  41. Ochratoxin A induces ER stress and apoptosis in mesangial cells via a NADPH oxidase-derived reactive oxygen species-mediated calpain activation pathway. Sheu ML, Shen CC, Chen YS, Chiang CK. Oncotarget. 2017 Mar 21;8(12):19376-19388. Impact Factor: 5.168, ONCOLOGY 44/127= 20.29%, 2016JCR
  42. Involvement of Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Advanced Glycation End Products-Induced Glomerular Mesangial Cell Injury. Chiang CK, Wang CC, Lu TF, Huang KH, Sheu ML*, Liu SH*, Hung KY. Scientific Reports. 2016 Sep 26;6:34167. Impact Factor: 4.259, MULTIDISCIPLINARY SCIENCES 10/64= 15.625%, 2016JCR
  43. Feasibility of Human Amniotic Fluid Derived Stem Cells in Alleviation of Neuropathic Pain in Chronic Constrictive Injury Nerve Model. Chiang CY, Liu SA, Sheu ML, Chen FC, Chen CJ, Su HL, Pan HC. PLoS One. 2016 Jul 21;11(7):e0159482.
  44. Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked Oxidative Stress-Regulated Autophagy-Activated Apoptosis and Cell Death in Microglial Cells. Chen CM, Wu CT, Yang TH, Chang YA, Sheu ML*, Liu SH*. Journal of Agricultural and Food Chemistry. 2016 May 25;64(20):4078-85.  Impact Factor: 3.154, AGRICULTURE, MULTIDISCIPLINARY  2/56= 3.57%, 2016JCR 
  45. Contrast Medium Exposure During Computed Tomography and Risk of Development of End-Stage Renal Disease in Patients With Chronic Kidney Disease: A Nationwide Population-Based, Propensity Score-Matched, Longitudinal Follow-Up Study. Hsieh MS, Chiu CS, How CK, Chiang JH, Sheu ML, Chen WC, Lin HJ, Hsieh VC, Hu SY. Medicine (Baltimore). 2016 Apr;95(16):e3388.
  46. The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction. Guan SS, Sheu ML, Yang RS, Chan DC, Wu CT, Yang TH, Chiang CK, Liu SH. Oncotarget. 2016 Apr 26;7(17):23072-87. Impact Factor: 5.168, ONCOLOGY 44/127= 20.29%, 2016JCR
  47. Iodinated Contrast Medium Exposure During Computed Tomography Increase the Risk of Subsequent Development of Thyroid Disorders in Patients Without Known Thyroid Disease: A Nationwide Population-Based, Propensity Score-Matched, Longitudinal Follow-Up Study. Hsieh MS, Chiu CS, Chen WC, Chiang JH, Lin SY, Lin MY, Chang SL, Sheu ML*, Hu SY*. Medicine (Baltimore). 2015 Dec;94(50):e2279. Impact Factor: 1.803, MEDICINE, GENERAL & INTERNAL 58/154= 37.66%, 2016JCR
  48. Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway. Chiu CY, Yang RS, Sheu ML*, Chan DC, Yang TH, Tsai KS, Chiang CK, Liu SH. The Journal of Pathology. 2016 Feb;238(3):470-82. Impact Factor: 6.894, PATHOLOGY 3/79= 3.79%, 2016JCR 
  49. Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBPβ and NFκB cleavage. Wu SM, Lin WY, Shen CC, Pan HC, Keh-Bin W, Chen YC, Jan YJ, Lai DW, Tang SC, Tien HR, Chiu CS, Tsai TC, Lai YL, Sheu ML*. Journal Of Pineal Research, 2016 Mar;60(2):142-54. Impact Factor: 10.391, PHYSIOLOGY 3/84= 3.57%, 2016JCR 【研究生獲選-12屆永信李天德醫藥科技獎-傑出論文獎】【研究生獲選-201714屆林榮耀教授學術教育基金會論文獎】
  50. Aryl Hydrocarbon Receptor Deficiency Attenuates Oxidative Stress-Related Mesangial Cell Activation and Macrophage Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy. Lee WJ, Liu SH, Chiang CK, Lin SY, Liang KW, Chen CH, Tien HR, Chen PH, Wu JP, Tsai YC, Lai DW, Chang YC, Sheu WH, Sheu ML*Antioxidants & Redox Signaling. 2016 Feb 1;24(4):217-231. Impact Factor: 6.337, ENDOCRINOLOGY & METABOLISM 13/138= 9.42%, 2016JCR
  51. ATP synthase subunit-β down-regulation aggravates diabetic nephropathy. Guan SS, Sheu ML, Wu CT, Chiang CK, Liu SH. Scientific Reports. 2015 Oct 9;5:14561. Impact Factor: 4.259, MULTIDISCIPLINARY SCIENCES 10/64= 15.625%, 2016JCR 
  52. Enhanced Allergic Inflammation of Der p 2 Affected by Polymorphisms of MD-2 Promoter. Liao EC, Hsieh CW, Chang CY, Yu SJ, Sheu ML, Wu SM, Tsai JJ. Allergy, Asthma & Immunology Research 2015 Sep;7(5):497-506.
  53. Increased survival with the combination of stereotactic radiosurgery and gefitinib for non-small cell lung cancer brain metastasis patients: a nationwide study in Taiwan. Lin CH, Hsu KH, Chang SN, Tsou HK, Sheehan J, Sheu ML, Pan HC. Radiation Oncology 2015 Jun 6;10:127.
  54. Correction: Correction: Cell-Penetrating Peptide Derived from Human Eosinophil Cationic Protein Inhibits Mite Allergen Der p 2 Induced Inflammasome Activation. Yu SJ, Liao EC, Sheu ML, Chang DT, Tsai JJ. PLoS One. 2015 Jun 1;10(6):e0129187.
  55. Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model. Chen CJ, Cheng FC, Su HL, Sheu ML, Lu ZH, Chiang CY, Yang DY, Sheehan J, Pan HC. PLoS One. 2015 May 6;10(5):e0124624
  56. Correction: Cell-Penetrating Peptide Derived from Human Eosinophil Cationic Protein Inhibits Mite Allergen Der p 2 Induced Inflammasome Activation. Yu SJ, Liao EC, Sheu ML, Margaret Chang DT, Tsai JJ. PLoS One. 2015 Apr 24;10(4):e0127255.
  57. Advanced glycation end-products induce apoptosis in pancreatic islet endothelial cells via NF-κB-activated cyclooxygenase-2/prostaglandin E2 up-regulation. Lan KC, Chiu CY, Kao CW, Huang KH, Wang CC, Huang KT, Tsai KS, Sheu ML*, Liu SH*. PLoS One. 2015 Apr 21;10(4):e0124418. Impact Factor: 3.057, MULTIDISCIPLINARY SCIENCES 15/64= 17.46%, 2015JCR
  58. Cell-penetrating peptide derived from human eosinophil cationic protein inhibits mite allergen Der p2 induced inflammasome activation. Yu SJ, Liao EC, Sheu ML, Chang DT, Tsai JJ. PLoS One. 2015 Mar 25;10(3):e0121393. Impact Factor: 3.057, MULTIDISCIPLINARY SCIENCES 15/64= 17.46%, 2015JCR
  59. Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition. Liu SH, Lee WJ, Lai DW, Wu SM, Liu CY, Tien HR, Chiu CS, Peng YC, Jan YJ, Chao TH, Pan HC, Sheu ML*Molecular Oncology. 2015 Apr;9(4):834-49. Impact Factor:5.331ONCOLOGY 28/211=13.27%, 2014JCR
  60. The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination. Lai DW, Liu SH, Karlsson AI, Lee WJ, Wang KB, Chen YC, Shen CC, Wu SM, Liu CY, Tien HR, Peng YC, Jan YJ, Chao TH, Lan KH, Arbiser JL, Sheu ML* Oncotarget. 2014 Sep 15;5(17):7788-804. Impact Factor: 6.359, ONCOLOGY 21/211= 9.95%, 2014JCR
  61. Deletion of the gene encoding the reductase component of 3-ketosteroid 9α-hydroxylase in Rhodococcus equi USA-18 disrupts sterol catabolism, leading to the accumulation of 3-oxo-23,24-bisnorchola-1,4-dien-22-oic acid and 1,4-androstadiene-3,17-dione. Yeh CH, Kuo YS, Chang CM, Liu WH, Sheu ML, Meng M. Microbial Cell Factories. 2014 Sep 9;13:130. doi: 10.1186/s12934-014-0130-3.
  62. CCAAT-Enhancer-Binding Protein Homologous Protein Deficiency Attenuates Oxidative Stress and Renal Ischemia-Reperfusion Injury. Chen BL, Sheu ML*, Tsai KS, Lan KC, Guan SS, Wu CT, Chen LP, Hung KY, Huang JW, Chiang CK, Liu SH. Antioxidants & Redox Signaling. 2015 Nov 20;23(15):1233-45. Impact Factor: 7.407, ENDOCRINOLOGY & METABOLISM 10/128= 7.75%, 2014JCR
  63. Nε-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction. Lee WJ, Sheu WH, Liu SH, Yi YC, Chen WC, Lin SY, Liang KW, Shen CC, Yeh HY, Lin LY, Tsai YC, Tien HR, Lee MR, Yang TJ, Sheu ML*. Free Radical Biology and Medicine. 2014 Sep;74:294-306. Impact Factor: 5.736, ENDOCRINOLOGY & METABOLISM 16/128= 12.5%, 2014JCR
  64. Detection of subtle neurological alterations by the Catwalk XT gait analysis system. Chen YJ, Cheng FC, Sheu ML, Su HL, Chen CJ, Sheehan J, Pan HC. Journal of NeuroEngineering and Rehabilitation. 2014 Apr 16;11:62.
  65. Comprehensive analysis of neurobehavior associated with histomorphological alterations in a chronic constrictive nerve injury model through use of the CatWalk XT system. Chiang CY, Sheu ML, Cheng FC, Chen CJ, Su HL, Sheehan J, Pan HC. Journal of Neurosurgery. 2014 Jan;120(1):250-62.
  66. Tpl2 inhibitors thwart endothelial cell function in angiogenesis and peritoneal dissemination. Lee WJ, Lan KH, Chou CT, Yi YC, Chen WC, Pan HC, Peng YC, Wang KB, Chen YC, Chao TH, Tien HR, Sheu WH, Sheu ML*. Neoplasia. 2013 Sep;15(9):1036-48. Impact Factor: 4.252, ONCOLOGY 49/211= 23.22%, 2014JCR
  67. Reciprocal modulation of C/EBP-α and C/EBP-β by IL-13 in activated microglia prevents neuronal death. Pan HC, Yang CN, Hung YW, Lee WJ, Tien HR, Shen CC, Sheehan J, Chou CT, Sheu ML*. European Journal of Immunology. 2013 Nov;43(11):2854-65. Impact Factor: 4.034, IMMUNOLOGY 39/148= 26.35%, 2014JCR
  68. Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model. Pan HC, Lai DW, Lan KH, Shen CC, Wu SM, Chiu CS, Wang KB, Sheu ML*. Carcinogenesis. 2013 Nov;34(11):2568-79. Impact Factor: 5.334, ONCOLOGY 27/211= 12.79%, 2014JCR
  69. Advanced glycation end products induce peroxisome proliferator-activated receptor γ down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor for advanced glycation end products. Chen YJ,  Sheu ML, Tsai KS, Yang RS, Liu SH. PLoS One. 2013 Jun 12;8(6):e66611. Impact Factor: 3.234, MULTIDISCIPLINARY SCIENCES 9/57= 15.78%, 2014JCR
  70. Mechanism of maprotiline-induced apoptosis: role of [Ca2+](i), ERK, JNK and caspase-3 signaling pathways. Jan CR, Su JA, Teng CC, Sheu ML, Lin PY, Chi MC, Chang CH, Liao WC, Kuo CC, Chou CT. Toxicology. 2013 Feb 8;304:1-12.
  71. Intracapsular decompression or radical resection followed by Gamma Knife surgery for patients harboring a large vestibular schwannoma. Pan HC, Sheehan J, Sheu ML, Chiu WT, Yang DY. Journal of Neurosurgery 2012 Dec;117 Suppl:69-77.
  72. Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. Liu SH, Wang KB, Lan KH, Lee WJ, Pan HC, Wu SM, Peng YC, Chen YC, Shen CC, Cheng HC, Liao KK, Sheu ML*. PLoS One. 2012;7(8):e43711. Impact Factor: 3.234, MULTIDISCIPLINARY SCIENCES 9/57= 15.78%, 2014JCR
  73. Advanced glycation end product Nε-carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation. Liu SH, Sheu WH, Lee MR, Lee WJ, Yi YC, Yang TJ, Jen JF, Pan HC, Shen CC, Chen WB, Tien HR, Sheu ML*. The Journal of Pathology. 2013 Jun;230(2):215-27. Impact Factor: 7.429, PATHOLOGY 4/76= 5.26 %, 2014JCR
  74. Intracapsular decompression or radical resection followed by Gamma Knife surgery for patients harboring a large vestibular schwannoma. Pan HC, Sheehan J, Sheu ML, Chiu WT, Yang DY. JOURNAL OF NEUROSURGERY. 2012 Dec;117 Suppl:69-77.
  75. Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. Liu SH, Wang KB, Lan KH, Lee WJ, Pan HC, Wu SM, Peng YC, Chen YC, Shen CC, Cheng HC, Liao KK, Sheu ML* PLoS One. 2012;7(8):e43711.
  76. Dual regeneration of muscle and nerve by intravenous administration of human amniotic fluid-derived mesenchymal stem cells regulated by stromal cell-derived factor-1α in a sciatic nerve injury model. Yang DY, Sheu ML, Su HL, Cheng FC, Chen YJ, Chen CJ, Chiu WT, Yiin JJ, Sheehan J, Pan HC. JOURNAL OF NEUROSURGERY. 2012 Jun;116(6):1357-67.
  77. Recruitment by SDF-1α of CD34-positive cells involved in sciatic nerve regeneration. Sheu ML, Cheng FC, Su HL, Chen YJ, Chen CJ, Chiang CM, Chiu WT, Sheehan J, Pan HC. JOURNAL OF NEUROSURGERY. 2012 Feb;116(2):432-44.
  78. Mite allergen Der-p2 triggers human B lymphocyte activation and Toll-like receptor-4 induction. Tsai JJ, Liu SH, Yin SC, Yang CN, Hsu HS, Chen WB, Liao EC, Lee WJ, Pan HC, Sheu ML*. PLoS One. 2011;6(9):e23249.
  79. Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model. Wu CT, Sheu ML, Tsai KS, Chiang CK, Liu SH. FREE RADICAL BIOLOGY AND MEDICINE. 2011 Aug 1;51(3):671-80.
  80. Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response. Pan HC, Sheu ML, Su HL, Chen YJ, Chen CJ, Yang DY, Chiu WT, Cheng FC. MAGNESIUM RESEARCH 2011 Jun;24(2):54-70.
  81. Honokiol inhibits hypoxia-inducible factor-1 pathway. Lan KL, Lan KH, Sheu ML, Chen MY, Shih YS, Hsu FC, Wang HM, Liu RS, Yen SH. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2011 Jun;87(6):579-90.
  82. Honokiol ameliorates renal fibrosis by inhibiting extracellular matrix and pro-inflammatory factors in vivo and in vitro. Chiang CK, Sheu ML, Lin YW, Wu CT, Yang CC, Chen MW, Hung KY, Wu KD, Liu SH. BRITISH JOURNAL OF PHARMACOLOGY. 2011 Jun;163(3):586-97.
  83. Quality-of-life outcomes after Gamma Knife surgery for trigeminal neuralgia. Pan HC, Sheehan J, Huang CF, Sheu ML, Yang DY, Chiu WT. JOURNAL OF NEUROSURGERY. 2010 Dec;113 Suppl:191-8.
  84. Radiosurgery for dural carotid-cavernous sinus fistulas: Gamma Knife compared with XKnife radiosurgery. Pan HC, Sun MH, Sheehan J, Sheu ML, Chen CC, Lee HT, Chiu WT, Yang DY. JOURNAL OF NEUROSURGERY. 2010 Dec;113 Suppl:9-20.
  85. Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals. Liu SH, Shen CC, Yi YC, Tsai JJ, Wang CC, Chueh JT, Lin KL, Lee TC, Pan HC, Sheu ML**. BRITISH JOURNAL OF PHARMACOLOGY. 2010 Aug;160(8):1963-72.
  86. IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death. Liu SH, Yang CN, Pan HC, Sung YJ, Liao KK, Chen WB, Lin WZ, Sheu ML* CELLULAR AND MOLECULAR LIFE SCIENCES. 2010 May;67(9):1465-76.
  87. The role of endoplasmic reticulum stress-related unfolded protein response in the radiocontrast medium-induced renal tubular cell injury. Wu CT, Sheu ML, Tsai KS, Weng TI, Chiang CK, Liu SH. TOXICOLOGICAL SCIENCES. 2010 Apr;114(2):295-301.
  88.  Enhancement of regeneration with glia cell line-derived neurotrophic factor-transduced human amniotic fluid mesenchymal stem cells after sciatic nerve crush injury. Cheng FC, Tai MH, Sheu ML, Chen CJ, Yang DY, Su HL, Ho SP, Lai SZ, Pan HC. JOURNAL OF NEUROSURGERY. 2010 Apr;112(4):868-79.
  89.  Escalated regeneration in sciatic nerve crush injury by the combined therapy of human amniotic fluid mesenchymal stem cells and fermented soybean extracts, Natto. Pan HC, Yang DY, Ho SP, Sheu ML, Chen CJ, Hwang SM, Chang MH, Cheng FC. JOURNAL OF BIOMEDICAL SCIENCE. 2009 Aug 23; 16:75.
  90. Potentiation of angiogenesis and regeneration by G-CSF after sciatic nerve crush injury. Pan HC, Wu HT, Cheng FC, Chen CH, Sheu ML, Chen CJ. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009 Apr 24;382(1):177-82.
  91.  Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis. Sheu ML, Chiang CK, Tsai KS, Ho FM, Weng TI, Wu HY, Liu SH. FREE RADICAL BIOLOGY AND MEDICINE. 2008 Jun 15;44(12):2043-50.
  92.  Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. Sheu ML*, Liu SH, Lan KH. PLoS ONE. 2007 Oct 31;2(10):e1096.
  93. HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines. Lan KH, Lan KL, Lee WP, Sheu ML, Chen MY, Lee YL, Yen SH, Chang FY, Lee SD.  JOURNAL OF HEPATOLOGY 2007 May;46(5):759-67.
  94. Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. Chiang CK, Sheu ML, Hung KY, Wu KD, S-H Liu. KIDNEY INTERNATIONAL. 2006 Aug;70(4):682-9.
  95. The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population. Lee WP, Tai DI, Lan KH, Li AF, Hsu HC, Lin EJ, Lin YP, Sheu ML, Li CP, Chang FY, Chao Y, Yen SH, Lee SD. CLINICAL CANCER RESEARCH. 2005 Sep 15;11(18):6431-41.
  96. Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the up-regulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells. Sheu ML, Chao KF, Sung YJ, Lin WW, Lin-Shiau SY , Liu SH. CELLULAR SIGNALLING. 2005 Aug;17(8):975-84. Epub 2004 Dec 15.
  97. High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway. Sheu ML, Ho FM, Yang RS, Chao KF, Lin WW, Lin-Shiau SY, Liu SH. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005 Jan 25(3):539-45.
  98. Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen species-related nuclear factor-kappaB activation and cyclooxygenase-2 expression in mesangial cells. Sheu ML, Ho FM, Chao KF, Kuo ML, Liu SH. MOLECULAR PHARMACOLOGY. 2004 Jul 66(1):187-96.
  99. Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma. Chung YL, Sheu ML, Yen SH. INTERNATIONAL JOURNAL OF CANCER. 2003 Oct 20;107(1):65-73.
  100. HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis. Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD. ONCOGENE. 2002 Jul 18;21(31):4801-11.
  101. Resistance to tamoxifen-induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer. Chung YL, Sheu ML, Yang SC, Lin CH, Yen SH. INTERNATIONAL JOURNAL OF CANCER. 2002 Jan 20;97(3):306-12.

 

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