林季千

林季千
教授兼所長
國立成功大學基礎醫學博士
生科大樓12樓1208室
(04)22840896＃132
chichenlin1@gmail.com

研究領域

主要研究方向：

1. 免疫細胞分子生物機轉探討

2. 免疫疾病動物模式之建立

3. 天然藥物之免疫調節活性探討

教授科目

上學期-核糖核酸疫苗特論(2學分)

上學期-高等免疫學(3學分)

上學期-細胞及分子免疫學(2學分)

下學期-基因治療特論(2學分)

下學期-動物細胞培養(3學分)

下學期-疫苗學(2學分)

簡要經歷

中興大學   生物醫學所                      所長                                                        2025/8~迄今

中興大學  生物科技發展中心   副主任                                                   2025/8~迄今

中興大學  生物科技發展中心   研發推動組  組長                        2024/8-2025/7

中興大學  生命科學院                     生醫產業研發中心   主任       2025/8~迄今

獲獎項目

1. 111年度中興大學懷璧獎 (2022)

2. 中興大學宏華興學基金（JHB Foundation）學術獎 (2025)

學術著作

  1. Huang YC, Tsai MJ, Lin CC*, Fu LS*.GLP-1 Agonists and Asthma Risk in Obese Adolescents: A Cohort Study. JAMA Network Open. 2025. (Accept)
  2. Huang YC, Cheng WC, Chao YH, Chen TT, Lin CC*. Targeting Protein Arginine Deiminases in Rheumatoid Arthritis: Pathophysiology and Therapeutic Progress. Biocell. 2025 (Accept)
  3. Hung WT, Liao HY, Sutopo CCY, Widyastuti E, Lin CC*, Hsu JL*. Perilla frutescens Seeds as a Source of Antihypertensive Peptides: Discovery of Novel Tetrapeptides with ACE Inhibitory Activity. Plant Foods Hum Nutr.  (2025/10), 2025;80(4):178
  4. Kung SP, Umbreen H, Wang JH, Tsia CM, Lin CC*, Chen YT*. Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice. Int J Immunopathol Pharmacol.  (2025/06), 39:3946320251348715
  5. Chen TT, Yang JC, Chen GY, Dai YH, Zhang X, Chan HL, Lin CC*, Wu YC*. Silibinin, as a PLC-β3 inhibitor, inhibited mast cell activation and alleviated OVA-induced asthma. Molecular Immunology.  (2025/02), 178:76-86
  6. Tang KT, Chen YH, Wang JH, Hsieh TY, Chao YH, Chen DY, Chen HH, Lin CC*. Autophagic Flux Might Be Blocked in Patients With Primary Antiphospholipid Antibody Syndrome. International Journal of Rheumatic Diseases.  (2025/03), 28(3):e70063
  7. Tang KT, Chen YS, Chen TT, Chao YH, Kung SP, Chen DY, Lin CC*. Inhibiting Tyrosine Kinase 2 Ameliorates Antiphospholipid Syndrome Nephropathy. Mediators of Inflammation.  (2024/12), 1:5568822
  8. Cheng WC, Chen PY, Zhang X, Chang YK, Tan KT, Lin CC*.5,7,3',4'-Tetramethoxyflavone suppresses TGF-β1-induced activation of murine fibroblasts in vitro and ameliorates bleomycin-induced pulmonary fibrosis in mice.  Immunopharmacology and Immunotoxicology . (2024/08), 46(4):496-508
  9. Wu PC, Chao YH, Zhang X, Chen TT, Kuo YH, Lin CC*, Chang HH*.Evaluation of the potential of Ergostatrien-3β-ol for treating Sjögren's syndrome. International journal of rheumatic diseases.  (2024/06), 12(7):1419
  10. Tang KT, Chen YS, Lee MF, Chen TT, Lai CC, Lin CC*, Chen YH*.Exposure to Volatile Organic Compounds May Contribute to Atopic Dermatitis in Adults.  Biomedicines.  (2024/06), 12(7):1419
  11. Kuo SL, Su CH, Lai KH, Chang YC, You JS, Peng HH, Chen CH, Lin CC*, Chen PJ*, Hwan TL*. Guizhi Fuling Wan ameliorates concanavalin A-induced autoimmune hepatitis in mice.  Biomedical Journal.  (2024/04), 10073
  12. Chen WC, Cheng WC, Chen CL, Liao WC, Chen CH, Chen HJ, Tu CY, Lin CC*. Assessing EGFR-Mutated NSCLC with Bone Metastasis: Clinical Features and Optimal Treatment Strategy. Cancer Medicine.   (2024/04), 13(7):e7152.
  13. Cheng WC, Lin CC*, Liao WC, Lin YC, Chen CH, Chen HJ, Tu CY, Hsia TC*. The difference between dacomitinib and afatinib in effectiveness and safety in first-line treatment of patients with advanced EGFR-mutant non-small cell lung cancer: a real-world observational study. BMC Cancer (2024/02), 24(1):228
  14. Huang LH, Chen CS, Li JR, Chiu KY, Wang SS, Yang CK, Cheng CL, Lin CC*, Ou YC*.The impact of squamous cell transformation on the prognosis of patients treated with radical nephroureterectomy.  BMC Cancer.  (2024/02), 24(1):247
  15. Tsai SW, Wang JH, Chang YK, Lin CC*.Erianin alleviates collagen induced arthritis in mice by inhibiting Th17 cell differentiation. Open Life Sciences.  (2023/12), 4;18(1):20220703.
  16. Tan KT, Shih YH, Gong JY, Zhang X, Huang CY, Su JH, Sheu JH , Lin CC*. Dihydroaustrasulfone alcohol induces apoptosis in nasopharyngeal cancer cells by inducing reactive oxygen species-dependent inactivation of the PI3K/AKT pathway.  Korean Journal of Physiology & Pharmacology.  (2023/07), 1;27(4):383-398
  17. Liao TL, Lin CC, Chen YH, Tang KT.Reduced miR-223 increases blood neutrophil extracellular trap and promotes skin inflammation in atopic dermatitis.  Allergy.  (2023/06)
  18. Umbreen H, Zhang X, Tang KT, Lin CC*. Regulation of Myeloid Dendritic Cells by Synthetic and Natural Compounds for the Treatment of Rheumatoid Arthritis. Int J Mol Sci. 2022 Dec 23;24(1):238
  19. Cheng YC, Zhang X, Lin SC, Li S, Chang YK, Chen HH*, Lin CC*.  Echinocystic Acid Ameliorates Arthritis in SKG Mice by Suppressing Th17 Cell Differentiation and Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes Inflammation.  Journal of Agricultural and Food Chemistry.  (2022/12), 70(51):16176-16187
  20. Tang KT, Chen HH, Chen TT, Bracci NR, Lin CC*. Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review.  Life (Basel).   (2021/08), 11(8):801
  21. Tan KT, Li S, Panny L, Lin CC*, Lin SC*.Galangin ameliorates experimental autoimmune encephalomyelitis in mice via modulation of cellular immunity.  Journal of Immunotoxicology.  (2021/03), 18(1):50-60
  22. Chen HL, Lin SC, Li S, Tang KT*, Lin CC*.Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling. Pharmaceutical Biology.  (2021/02), 59(1):134-145.
  23. Lin YC, Yang CC, Lin CH, Hsia TC, Chao WC, Lin CC*.Atractylodin Ameliorates Ovalbumin-Induced Asthma in a Mouse Model and exerts immunomodulatory effects on Th2 Immunity and Dendritic cells Function. Molecular Medicine Reports.  (2020/12), 22(6):4909-4918.
  24. Chuang CH, Cheng YC, Lin SC, Lehman CW, Wang SP, Chen DY, Tsai SW, Lin CC*. Atractylodin Suppresses Dendritic Cell Maturation and Ameliorates Collagen-Induced Arthritis in a Mouse Model.  Journal of Agricultural and Food Chemistry.  (2019/06), 67(24):6773–6784
  25. Yang G, Li S*, Yang Y, Yuan L, Wang P, Zhao H, Ho CT, Lin CC* .Nobiletin and 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4+ T Cells through Mitogen-Activated Protein Kinase Signaling Pathways. Journal of Agricultural and Food Chemistry.  (2018/08), 66(31):8299-8306
  26. Lin CC*, Wu JJ*, Pan YG, Chao YH, Lin FC, Lee YR, Chu CL. Gold Lotion from Citrus Peel Extract Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in murine.  Journal of the Science of Food and Agriculture.  (2018/04), doi: 10.1002/jsfa.9097
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