Chih-Chen Lin

腫瘤免疫學, 自體免疫學, 天然物及有機化學合成藥物生物活性之探討
主要研究方向，包括:
1. 免疫樹狀細胞 (dendritic cells)於癌症及自體免疫疾病之細胞分子生物機轉及其於免疫治療之應用
2. 免疫疾病及癌症動物模式之建立
3. DNA疫苗之開發

上學期-核糖核酸疫苗特論(2學分)
上學期-高等免疫學(3學分)
上學期-細胞及分子免疫學(2學分)
下學期-基因治療特論(2學分)
下學期-動物細胞培養(3學分)
下學期-疫苗學(2學分)

A. 期刊論文

1. Chuang CH, Cheng YC, Li S, Lin SC, Lehman CW, Chen DY, Tsai SW, Lin CC*. Atractylodin suppresses dendritic cell maturation and ameliorates collagen-induced arthritis in a mouse model.J Agric Food Chem. 2019 Jun 2.(SCI)
2. Tan KT, Hsieh TY, Chao YH, Li JP, Lan JF, Lin CC*, Chen DY.Apoptosis in patients with primary antiphospholipid antibody syndrome.International Journal of Rheumatic Diseases. 2018, Dec, accept (SCI)
3. Ahmed AF, Chen YW, Huang CY, Tseng YJ, Lin CC, Dai CF, Wu YC, Sheu JH. Isolation and Structure Elucidation of Cembranoids from a Dongsha  Atoll Soft Coral Sarcophyton stellatum. Marine Drugs. 2018, Jun 14;16(6). pii: E210. doi: 10.3390/md16060210. (SCI)
4. Chao YH, Chen DY, Lan JL, Tan KT, Lin CC*. Tolerogenic β2-glycoprotein I DNA Vaccine and FK506 as an Adjuvant Attenuates Experimental Obstetric Antiphospholipid Syndrome. PLoS One. 2018, Jun 12; 13(6):e0198821.  doi: 10.1371/journal.pone.0198821. eCollection 2018. (SCI)
5. Lee SW, Lien HC, Lin CC, Wen MC, Chang CS. Low Expression of Transforming Growth Factor β in the Epithelium of Barrett's Esophagus. Gastroenterology Res. 2018 Jun;11(3):189-194. doi: 10.14740/gr1009w. Epub 2018 May 31. (SCI)
6. Lin CC*, Wu JJ, Pan YG, Chao YH, Lin FC, Lee YR, Chu CL. Gold Lotion from Citrus Peel Extract Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in murine. J Sci Food Agric. 2018 Apr 24. doi: 10.1002/jsfa.9097. (SCI)
7. Tsai SW, Hsieh MC, Li S, Lin SC, Wang SP, Lehman CW, Lien CZ, Lin CC*. Therapeutic Potential of Sclareol in Experimental Models of Rheumatoid Arthritis. Int J Mol Sci. 2018 May 3;19(5). (SCI)
8. Lin MX, Lin SH, Li YR, Chao YH, Lin CH, Su JH, Lin CC*. Lobocrassin B Induces Apoptosis of Human Lung Cancer and Inhibits Tumor Xenograft Growth. Mar Drugs. 2017 Dec 4;15(12). pii: E378. doi: 10.3390/md15120378. (SCI)
9. LI YR, Li S, Lin CC*. Effect of Resveratrol and Pterostilbene on Aging and Longevity. Biofactor. 2018 Jan;44(1):69-82. doi: 10.1002/biof.1400. Epub 2017 Dec 6. (SCI)
10. Tang KT, Hsieh TY, Chao YH, Lin MX, Chen YH, Chen DY, Lin CC*. Plasma levels of high-mobility group box 1 and soluble receptor for advanced glycation end products in primary antiphospholipid antibody syndrome patients.PLoS One. 2017 May 30;12(5):e0178404 (SCI)
11. Lin SC, Ho CT, Chuo WH, Li S, Wang TT*, Lin CC*. Effective inhibition of MERS-CoV infection by resveratrol.BMC Infect Dis. 2017 Feb 13;17(1):144. (SCI)
12. Lin PY, Tsai CT, Chuang WL, Chao YH, Pan IH, Chen YK, Lin CC*, Wang BY*.Chlorella sorokiniana induces mitochondrial-mediated apoptosis in human non-small cell lung cancer cells and inhibits xenograft tumor growth in vivo.BMC Complement Altern Med. 2017 Feb 1;17(1):88 (SCI)
13. Li YR, Chen DY, Chu CL, Li S, Chen YK, Wu CL, Lin CC*. , “Naringenin inhibits dendritic cell maturation and has therapeutic effects in a murine model of collagen-induced arthritis ,” The Journal of Nutritional Biochemistry, 12 2015. (SCI)
14. Chen HH, Chen DY, Chao YH, Chen YM, Wu CL, Lai KL, Lin CH, Lin CC*. , “Acarbose Decreases the Rheumatoid Arthritis Risk of Diabetic Patients and Attenuates the Incidence and Severity of Collagen-induced Arthritis in Mice. ,” Scientific Reports , 12 2015. (SCI)
15. Lin MK, Lee MS, Chang WT, Chen HY, Chen JF, Li YR, Lin CC*, Wu TS*. , “Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity response,” Bioorganic & Medicinal Chemistry Letters , 10 2015. (SCI)
16. Chen Y, Chen YM, Lin CC, Hsieh CW, Wu YC, Hung WT, Chen HH, Lan JL, “The potential role of advanced glycation end products (AGEs) and soluble receptors for AGEs (sRAGE) in the pathogenesis of adult-onset still's disease.,” BMC Musculoskelet Disord. , vol.16, no.1, pp.11, 05 2015. (SCI)
17. Chuang WL, Su CC, Lin PY, Lin CC, Chen YL., “Sann-Joong-Kuey-Jian-Tang induces autophagy in HepG2 cells via regulation of the phosphoinositide-3 kinase/Akt/mammalian target of rapamycin and p38 mitogen-activated protein kinase pathways.,” Mol Med Rep, 2015 Aug;12(2):1677-84. doi: 10.3892/mmr.2015.3573. Epub 2015 Mar 31. (SCI)
18. Chen DY, Chen YM, Hsieh TY, Hsieh CW, Lin CC, Lan JL, “Significant effects of biologic therapy on lipid profiles and insulin resistance in patients with rheumatoid arthritis.,” Arthritis Res Ther., vol.17(1):559, 03 2015. (SCI)
19. Chen SY, Shiau AL, Li YT, Lin CC, Jou IM, Liu MF, Wu CL, Wang CR, “Transcription factor snail regulates tumor necrosis factor α-mediated synovial fibroblast activation in the rheumatoid joint,” Arthritis Rheumatol. , vol.67(1):, pp.39-50, 01 2015. (SCI)
20. Lin CC*, Chen JT*, Lin MW*, Chan CH*, Wen YF, Wu SB, Chung TW, Lyu KW, Chou HC, Chan HL.Identification of protein expression alterations in gefitinib-resistant human lung adenocarcinoma: PCNT and mPR play key roles in the development of gefitinib-associated resistance.Toxicol Appl Pharmacol. 2015 Nov 1;288(3):359-73 (SCI)
21. .Li S, Lin YC, HoCT, Lin PY, Pan IH, Michiko S, Wang HC, Chu CL, Chen DY, Lin CC*, “Formulated Extract from Multiple Citrus Peels Impairs Dendritic Cell Functions and Attenuates Allergic Contact Hypersensitivity,” International Immunopharmacology, 2014 May;20(1):12-23. doi: 10.1016/j.intimp.2014.02.005. Epub 2014 Feb 22. (SCI)
22. Chen DY, Yao L, Chen YM, Lin CC, Huang KC, Chen ST, Lan JJ, Hsieh SL, “A Potential Role of Myeloid DAP12-Associating Lectin (MDL)-1 in the Regulation of Inflammation in Rheumatoid Arthritis Patients,” PLOSone, 2014 Jan 21;9(1):e86105. doi: 10.1371/journal.pone.0086105. eCollection 2014. (SCI)
23. Huang HJ*, Lin CC*, Chou HC, Chen YW, Lin ST, Lin YC, Lin DY, Lyu KW, Chan HL.Proteomic analysis of rhein-induced cyt: ER stress mediates cell death in breast cancer cells.Mol Biosyst. 2014 Dec;10(12):3086-100 (SCI)
24. Weng TY, Huang SS, Yen MC, Lin CC, Chen YL, Lin CM, Chen WC, Wang CY, Chang JY, Lai MD, “A Novel Cancer Therapeutic Using Thrombospondin 1 in Dendritic Cells.,” Molecular Therapy, 2014 Feb;22(2):292-302. doi: 10.1038/mt.2013.236. Epub 2013 Oct 15. (SCI)
25. Chen DY, Song PS, Hong JS, Chu CL, Pan IH, Chen YM, Lin CH, Lin SH, Lin CC* , “ Dextromethorphan Inhibits Activations and Functions in Dendritic Cells,” Clinical and Developmental Immunology, 2013;2013:125643. doi: 10.1155/2013/125643. Epub 2013 May 28. (SCI)
26. Chen DY*, Lin CC*, Chen YM, Lan JL, Hung, WT, Chen HH, Lai KL, Hsieh CW, “Involvement of TLR7 MyD88-dependent signaling pathway in the pathogenesis of adult-onset Still's disease,” Arthritis Research & Therapy, 2013 Mar 4;15(2):R39. doi: 10.1186/ar4193. (SCI)
27. Li YT, Chen SY, Wang CR, Liu MF, Lin CC, Jou IM, Shiau AL, Wu CL, “Amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223.,” Arthritis Rheum., 2012 Oct;64(10):3240-5. doi: 10.1002/art.34550. (SCI)
28. Huang HC, Chen YR, Lin CC*., “Antrodia cinnamomea (a. camphorata, neu chang chih): an exceptional polypore mushroom with potential antitumor and immuno-modulatory effects.,” Current Topics In Nutraceutical Research. 2012,10(1). (SCI)
29. Huang ZT*,Yen MC*, Lin CC, Weng TY, Chen YL, Lin CM, Lai MD., “Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces anti-tumor immunity against orthotopic and metastatic liver cancer,” Cancer Science, 09 2011. (SCI)
30. Chen DY, Chen YM, Chen HH, Hsieh CW, Lin CC, Lan JL., “Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-alpha therapy,” Arthritis Research & Therapy, vol.13 (4), pp.R 126, 07 2011. (SCI)
31. Lin CC*, Yu YL, Shih CC, Liu KJ, Hong LZ, Chen Jody D.C. Chu CL, “A Novel Adjuvant Ling Zhi-8 Enhances the Efficacy of DNA Cancer Vaccine by Activating Dendritic Cells,” Cancer Immunology Immunotherapy, vol.60 (7), pp.1019-1027, 07 2011. (SCI)
32. Wang ST, Chang CC, Yen MC, Tu CF, Chu CL, Peng YT, Chen DY, Lan JL, Lin CC*, “RNA interference-mediated silencing of Foxo3 in antigen-presenting cells as a strategy for the enhancement of DNA vaccine potency.,” Gene Therapy, vol.18 (4), pp.372-383, 04 2011. (SCI)
33. Chen DY, Shen GH, Chen YM, Chen HH, Lin CC, Hsieh CW, Lan JL, “Interferon-inducible protein-10 as a marker to detect latent and active tuberculosis in rheumatoid arthritis,” The International Journal of Tuberculosis and Lung Disease, vol.15 (2), pp.192-199, 02 2011. (SCI)
34. Chen SY, Wu CL, Lai MD, Lin CC, Yo YT, Jou IM, Lee CH, Weng CT, Shiau AL, Wang CR, “Amelioration of Rat Collagen-induced Arthritis through CD4+ T Cells Apoptosis and Synovial Interleukin-17 Reduction by Indoleamine 2,3-dioxygenase,” Human Gene Therapy, vol.22 (2), pp.145-154, 02 2011. (SCI)
35. Chu CL, Chen DC, Lin CC*., “A Novel Adjuvant Ling Zhi-8 for Cancer DNA Vaccines. (Invited Commentary),” Human Vaccine, vol.7 (11), 2011. (SCI)
36. Huang CS, Chang CC, Lin CM, Wang ST, Wu MT, Li IC, Chang HS, Lin CC*. , “Promoting effect of antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of Her-2/neu dna vaccine. Cancer Immunology Immunotherapy,” Cancer Immunology Immunotherapy, vol.59 (8), pp.1259-1272, 08 2010. (SCI)
37. Yen MC, Lin CC, Chen YL, Huang SS, Yang HJ, Chang CP, Lei HY, Lai MD., “A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA,” Clinical Cancer Research, vol.15 (2), pp.641-649, 01 2009. (SCI)
38. Lin CC*, Yen MC, Lin CM, Huang SS, Yang HJ, Chow NH, Lai MD., “Delivery of noncarrier naked DNA vaccine into the skin by supersonic flow induces a polarized T helper type 1 immune response to cancer,” The Journal of Gene Medicine , vol.10 (6), pp.679-689, 06 2008. (SCI)
39. Lin CC*, Yang HJ, Tu CF, Lai MD., “The opposing effects of lipopolysaccharide on the antitumor therapeutic efficacy of DNA vaccine,” DNA and Cell Biology, vol.27 (3), pp.151-157, 03 2008. (SCI)
40. Lin CC*, Tu CF, Yen MC, Chen MC, Hsieh WJ, Chang WC, Chang WT, Lai MD., “Inhibitor of heat-shock protein 90 enhances the antitumor effect of DNA vaccine targeting clients of heat-shock protein,” Molecular Therapy, vol.15 (2), pp.404-410, 02 2007. (SCI)
41. Tu CF#, Lin CC#, Chen MC, Ko TM, Lin CM, Wang YC, Lai MD. , “Autologous neu DNA vaccine can be as effective as xenogenic neu DNA vaccine by altering administration route,” Vaccine, vol.25 (4), pp.719-728, 01 2007. (SCI)
42. Lin CC*, Chou CW, Shiau AL, Tu CF, Ko TM, Chen YL, Yang BC, Tao MH, Lai MD. , “Therapeutic HER2/Neu DNA vaccine inhibits mouse tumor naturally overexpressing endogenous neu,” Molecular Therapy, vol.10 (2), pp.290-301, 08 2004. (SCI)