Meei-Ling Sheu

1. Molecular Toxicology and Immunotoxicology
2. Metabolism and Vascular Biomedicine
3. Endoplasmic reticulum pressure causes gastrointestinal inflammation and canceration and peritoneal metastasis-gastric cancer, colorectal cancer
4. Diabetes glycation end product metabolism and vascular biomedicine-large and small vascular disease
5. Natural medicines and new chemical compounds are developed in animal toxicity testing and image analysis

Last Semester-Toxicology (2 credits)

Last Semester-Toxic and Receptor Interaction (2 credits)

Last Semester-Special Topics in Biotechnology and Biotechnology Experiments (1) (3 credits)

Last Semester-Special Topics on Message Transmission and Human Diseases (1) (2 credits)

Last Semester-Free Radicals and Oxidative Stress (2 credits)

Next Semester-Molecular Toxicology (2 credits)

Next Semester-Environmental Toxicology (2 credits)

Next Semester-Special Topics in Biotechnology and Biotechnology Experiments (2) (3 credits)

Next Semester-Special Topics on Message Transmission and Human Diseases (2) (2 credits)

Next semester-Endoplasmic Reticulum Pressure (2 credits)

Whole school year-Advanced Angiogenesis and Experiment (6 credits)

Full academic year-Special Topics in Nitric Oxide Biology (4 credits)

[University Department] Next Semester-Introduction to Toxicology (3 credits)

Distinguished Professor 2018/08-2020/07 Zhongxing University Biomedical Research Institute

Professor 2014/02-So far Zhongxing University Biomedical Research Institute
Associate Professor 2011/02-2014/01 Biomedical Research Institute, Zhongxing University
Assistant Professor 2009/08-2011/01 Institute of Biomedicine, School of Student Sciences, Zhongxing University
Assistant Professor 2007/02-2009/07 Institute of Medical Science and Technology, National Academy of Student Sciences, Zhongxing University
Assistant Professor 2005/08-2007/01 Department of Medical Laboratory Science, Zhongshan Medical University
Postdoctoral researcher 2005/02-2005/07 National Taiwan University School of Medicine
PhD, 2000/09-2005/02 Institute of Toxicology, National Taiwan University School of Medicine
Research Assistant 1999/08-2000/07 Taipei Rong General Cancer Center
Master's degree 1997/09-1999/06 Institute of Anatomy and Cell Biology, Yangming University
Junior High School Teacher 1993/07-1997/07 Kaohsiung City Nanzi Junior High School Biology Teacher

★2019指導生科系大學部王信傑同學榮獲2019年台灣生化學會秋令營研討會壁報論文競賽-佳作

★2019指導生科系大學部王信傑同學榮獲台灣基因體暨遺傳學會2019年轉譯醫學學術研討會暨學術論文競賽壁報論文競賽-佳作

●2019「107年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽―第一名

★2019指導吳昇懋同學榮獲第16屆中華民國解剖學學會碩博士研究生學術論文競賽博士組―第二名

★2019指導歐蕙葶同學榮獲第16屆中華民國解剖學學會碩博士研究生學術論文競賽碩士組―第三名

★ 2019指導邢相媛同學榮獲第24屆台灣癌症聯合學術年會壁報論文競賽『基礎轉譯組』―佳作

★2019指導吳昇懋同學榮獲第34屆生物醫學聯合學術年會中華民國毒物學學會口頭論文競賽榮獲―第一名

★2019指導邢相媛同學榮獲第16屆中華民國解剖學學碩博士研究生學術論文競賽碩士組-佳作

★2019指導吳昇懋同學榮獲第一屆台灣毒理學學會墾丁冬令營英文口頭論文競賽–第三名

★2019指導邢相媛同學榮獲第一屆台灣毒理學學會墾丁冬令營英文口頭論文競賽–佳作

★2019指導歐蕙葶同學榮獲第一屆台灣毒理學學會墾丁冬令營海報論文競賽–佳作

★2018指導張育瑄同學榮獲中國材料科學學會海報論文競賽–特優

★2018指導張育瑄同學榮獲台灣化學工程學會65周年年會暨科技部化學工程學門成果發表會壁報論文競賽-佳作

★2018指導張育瑄同學榮獲中華民國尖端材料科技學會論文比賽-特優

★2018指導歐蕙葶同學榮獲2018中華實驗動物學會第十五屆第二次會員大會暨學術研討會-壁報論文第四名

★2018指導邢相媛同學榮獲台灣基因體暨遺傳學會2018年轉譯醫學學術研討會暨學術論文競賽-口頭報告第三名

★2018指導賴德偉同學參加14屆永信李天德醫藥科技獎，榮獲:傑出論文獎

●2018「106年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽―第一名

★2018指導謝宜真同學榮獲第23屆台灣癌症聯合學術年會壁報論文競賽『基礎轉譯組』―第八名

★2018指導林聖涵同學榮獲第23屆台灣癌症聯合學術年會壁報論文競賽『基礎轉譯組』―佳作

★2018指導林聖涵同學榮獲第15屆中華民國解剖學學碩博士研究生學術論文競賽碩士組-第一名

★2018指導沈軒宇同學榮獲獎第15屆中華民國解剖學學碩博士研究生學術論文競賽碩士組-佳作

★2018指導呂庭宇同學榮獲第33屆生物醫學聯合學術年會台灣生物化學及分子生物學學會壁報論文競賽-佳作

★2018指導賴德偉同學榮獲中華民國內分泌暨糖尿病學會第十三屆第三次會員大會暨學術研討會壁報比賽:第一名

★2017指導賴德偉同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-口頭報告:第一名

★2017指導謝宜真同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-口頭報告:優秀獎

★2017指導呂庭宇同學榮獲2017年台灣生化學會秋令營研討會壁報論文競賽-佳作

★2017指導林聖涵同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-壁報比賽:優秀獎

★2017指導吳昇懋同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-壁報比賽:優秀獎

★2017指導沈軒宇同學榮獲台灣基因體暨遺傳學會2017年轉譯醫學學術研討會暨學術論文競賽-壁報比賽:優秀獎

★2017指導賴德偉同學榮獲2017第14屆林榮耀教授學術教育基金會論文獎

★2017指導吳昇懋同學榮獲2017第14屆林榮耀教授學術教育基金會論文獎

●國軍退除役官兵輔導委員會台中榮總105年度研究發展―特優獎

★2017指導賴德偉同學參加32屆生物醫學聯合學術年會中華民國毒物學學會口頭論文競賽榮獲―第一名

★2017指導賴德偉同學參加32屆生物醫學聯合學術年會台灣生化學會研究生壁報論文競賽榮獲―優秀壁報論文獎

★2017指導盧柏超同學參加15屆中華民國解剖學學會碩博士研究生壁報論文競賽-碩士組第一名

★2017指導賴德偉同學參加15屆中華民國解剖學學會碩博士研究生壁報論文競賽-博士組第二名

★2017指導賴德偉同學參加22屆台灣癌症聯合學術年會壁報論文競賽『基礎轉譯組』―第七名

★2016指導吳昇懋同學參加12屆永信李天德醫藥科技獎，榮獲-傑出論文獎

★2016指導盧柏超同學參加台灣基因體暨遺傳學會2016年轉譯醫學學術研討會暨學術論文競賽壁報比賽―優秀獎

★2016指導沈軒宇同學參加台灣基因體暨遺傳學會2016年轉譯醫學學術研討會暨學術論文競賽壁報比賽―優秀獎

★2016指導吳昇懋同學參加第30屆天然藥物研討會藥學暨中醫藥學門成果發表會―壁報論文優秀獎藥理組第二名
★2016指導碩士班研究生湯舒晴同學參加生醫年會解剖學會的學術論文競賽-佳作
★2016指導博士班研究生吳昇懋同學參加中華民國細胞及分子生物學會榮獲―徐千田優秀論文獎
★2015指導碩士班研究生湯舒晴同學參加台灣生化學會秋令營研討會―優秀壁報論文獎
★2015指導碩士班研究生張以潔同學參加台灣生化學會秋令營研討會―優秀壁報論文獎
●國軍退除役官兵輔導委員會台中榮總103年度研究發展―特優獎
●2015台中榮總與中區各大學合作研究計劃聯合成果發表論文競賽―優良論文
●2015「103年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽―第一名
★2015指導博士班研究生賴德偉同學參加第二十九屆生物醫學聯合學術年會中華民國毒物學學會論文壁報競賽榮獲―佳作
★2015指導碩士班研究生劉珈妤同學參加第二十九屆生物醫學聯合學術年會中華民國毒物學學會口頭論文競賽榮獲―佳作
★2014指導碩士班研究生劉珈妤同學參加103年台灣基因醫學暨生物標記學會論文壁報競賽榮獲―金質獎
●2014實驗室獲選―「基因醫學教育推廣優秀單位」
★2014指導碩士班研究生劉珈妤同學參加103年台灣基因醫學暨生物標記學會「第二屆全國基因廣角鏡徵文比賽」―銅質獎
★2014指導中興大學生科系蔡宗志同學參加第十四屆中華民國解剖學學會大學組學術論文競賽―第一名
★2014指導中興大學生科系蔡宗志同學參加生科院學士研究成果壁報競賽―特優獎
●2014第六屆亞太拜耳華人糖尿病論壇―ABCD最佳基礎研究獎
★2014指導碩士班研究生劉珈妤同學參加第十三屆中華民國解剖學學會碩士班學術論文競賽―第二名
●103年度「國立中興大學優秀年輕學者獎助計畫（懷璧獎）」生命科學組 
★2013指導碩士班研究生劉珈妤同學參加2013年的台灣生物化學及分子生物學學會冬令營榮獲碩士班組口頭論文競賽―第一名
★2013指導博士班研究生賴德偉同學參加2013年的台灣生物化學及分子生物學學會冬令營榮獲博士班組壁報論文獎―佳作
★2013指導博士班研究生賴德偉同學參加「102年台灣基因醫學暨生物標記學會年會暨基因醫學臨床應用研討會」論文競賽榮獲―「普生優秀論文銅質獎」
●2013實驗室獲選「基因醫學教育推廣優秀單位」
★2013指導碩士班研究生賴德偉同學參加第28屆生物醫學年會毒理學會-口頭競賽―第二名
★2013指導碩士班研究生賴德偉同學參加2013台灣蛋白體年會暨國際轉譯醫學新知研討會壁報論文獎―佳作
★2013共同指導助理蔡怡青小姐參加「101年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」口頭論文競賽―第一名
★2013共同指導助理蔡怡青小姐參加「101年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽―第一名
★2013共同指導助理陳霈萱小姐參加「101年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」壁報論文競賽―第二名
★2013指導碩士班研究生賴德偉同學參加2013生物醫學研究所碩士班口頭論文競賽―第一名
●2013參加第五屆亞太拜耳華人糖尿病論壇ABCD最佳口頭報告一等獎
★2013指導助理田幸茹小姐參加台灣基因醫學暨生物標記學會比賽―特別獎
★2013指導助理蔡怡青小姐參加台灣基因醫學暨生物標記學會比賽―特別獎
★2013指導碩士班研究生賴德偉同學參加2013年的台灣生物化學及分子生物學學會惠蓀林場冬令營榮獲口頭論文競賽―第二名
★2013指導碩士班研究生賴德偉同學參加2013年的生物醫學年會台灣生物化學及分子生物學學會海報論文競賽―優等
★2012指導助理田幸茹小姐參加「100年度中區各大院校暨台中榮民總醫院合作研究計畫聯合成果發表會」論文競賽―第一名
★2012指導碩士班研究生吳昇懋同學參加101年台灣基因醫學暨生物標記學會/基因標記暨轉譯醫學應用研討會壁報論文競賽―第二名
★2012指導碩士班研究生陳怡靜同學參加中華民國解剖學學會第12屆壁報論文競賽―第一名
★2012指導碩士班研究生蔡怡青同學參加第27屆生物醫學年會毒理學會口頭競賽―第二名
★2012指導碩士班研究生陳怡靜同學參加2012生物醫學研究所碩士班口頭論文競賽―第一名
★2012指導碩士班研究生吳昇懋同學參加2012生物醫學研究所碩士班口頭論文競賽―第二名
★2012指導碩士班研究生蔡怡青同學參加2012生物醫學研究所碩士班口頭論文競賽―第四名
★2012指導碩士班研究生吳昇懋同學參加2012轉譯醫學之基因體與蛋白質體之臨床應用學術研討會壁報論文比賽―佳作
★2012指導助理田幸茹小姐參加2012轉譯醫學之基因體與蛋白質體之臨床應用學術研討會壁報論文比賽―第二名
其他
★2010指導助理田幸茹小姐參加台中榮民總醫院與中興大學合作研究計畫聯合研究成果發表壁報論文競賽―第一名
★2009台中榮民總醫院與中興大學合作研究計畫聯合研究成果發表壁報論文競賽―第三名
★2009指導碩士班研究生王致堅同學參加二十四屆生物醫學聯合學術年會議毒物學學會優秀學術壁報―論文獎
★2009指導研究生王致堅同學參加九十八年基因體與蛋白質體學術研討會壁報比賽―第一名
●2007第二十二屆生物醫學聯合學術會議毒物學學會優秀學術論文獎―佳作獎
●2006中山醫學大學教師學術研究著作―論文獎 
●2006財團法人杏園基金會學術論文獎
●2005台灣大學醫學院研究生優秀著作獎―優等獎
●2005台灣大學醫學院研究生論文優秀獎學金
●2004第十九屆生物醫學聯合學術會議毒理學會優秀論文選拔―第一名
●2003中華民國毒理學學會第一屆春令營論文競賽―第二名
●1999陽明大學學術論文競賽壁報展―第五名
●1999陽明醫學教育基金會獎學金
●1999紀念尹珣若先生品學及論文優秀獎學金
●1999中華民國解剖學學會研究生論文競賽―第一名

Meei-Ling Sheu

1. Exploiting Honokiol-induced ER stress CHOP activation inhibits the growth and metastasis of melanoma by suppressing the MITF and β-catenin pathways. Chiu CS, Tsai CH, Hsieh MS , Tsai SC, Jan YJ, Lin WY, Lai DW, Wu SM, Hsing HY, Arbiser JL, Sheu ML*. Cancer Letters. 2018 Nov 1;442:113-125 【Impact Factor: 6.491, ONCOLOGY 29/223=13%, 2017JCR】
2. Therapeutic Targeting Tumor Progression Locus-2 (TPL2)/Activating Transcription Factor-4 (ATF4)/Chemokine Stromal Cell-Derived Factor-α (SDF1α) Axis Suppresses Diabetic Retinopathy. Lai DW, Lin KH, Sheu WH, Lee MR, Chen CY, Lee WJ, Hung YW, Shen CC, Chung TJ, Liu SH, Sheu ML*. Circulation Research 2017 Sep 1;121(6):e37-e52. 【Impact Factor: 13.965, HEMATOLOGY 1/70=1.42%, 2016JCR】 【研究生獲選-2017第14屆林榮耀教授學術教育基金會論文獎】【第14屆永信李天德醫藥科技獎，研究生獲選-傑出論文獎】
3. Prevention of Axonal Degeneration by Perineurium Injection of Mitochondria in a Sciatic Nerve Crush Injury Model. Kuo CC, Su HL, Chang TL, Chiang CY, Sheu ML, Cheng FC, Chen CJ, Sheehan J, Pan HC. Neurosurgery. 2017 Mar 1;80(3):475-488.
4. Activation of PI3K in response to high glucose leads to regulation of SOCS-3 and STAT1/3 signals and induction of glomerular mesangial extracellular matrix formation. Sheu ML, Shen CC, Jheng JR, Chiang CK. Oncotarget. 2017 Mar 7;8(10):16925-16938. 【Impact Factor: 5.168, ONCOLOGY 44/127=20.29%, 2016JCR】
5. Ochratoxin A induces ER stress and apoptosis in mesangial cells via a NADPH oxidase-derived reactive oxygen species-mediated calpain activation pathway. Sheu ML, Shen CC, Chen YS, Chiang CK. Oncotarget. 2017 Mar 21;8(12):19376-19388. 【Impact Factor: 5.168, ONCOLOGY 44/127=20.29%, 2016JCR】
6. Involvement of Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Advanced Glycation End Products-Induced Glomerular Mesangial Cell Injury. Chiang CK, Wang CC, Lu TF, Huang KH, Sheu ML*, Liu SH*, Hung KY. Scientific Reports. 2016 Sep 26;6:34167. 【Impact Factor: 4.259, MULTIDISCIPLINARY SCIENCES 10/64=15.625%, 2016JCR】
7. Feasibility of Human Amniotic Fluid Derived Stem Cells in Alleviation of Neuropathic Pain in Chronic Constrictive Injury Nerve Model. Chiang CY, Liu SA, Sheu ML, Chen FC, Chen CJ, Su HL, Pan HC. PLoS One. 2016 Jul 21;11(7):e0159482.
8. Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked Oxidative Stress-Regulated Autophagy-Activated Apoptosis and Cell Death in Microglial Cells. Chen CM, Wu CT, Yang TH, Chang YA, Sheu ML*, Liu SH*. Journal of Agricultural and Food Chemistry. 2016 May 25;64(20):4078-85. 【Impact Factor: 3.154, AGRICULTURE, MULTIDISCIPLINARY  2/56=3.57%, 2016JCR】
9. Contrast Medium Exposure During Computed Tomography and Risk of Development of End-Stage Renal Disease in Patients With Chronic Kidney Disease: A Nationwide Population-Based, Propensity Score-Matched, Longitudinal Follow-Up Study. Hsieh MS, Chiu CS, How CK, Chiang JH, Sheu ML, Chen WC, Lin HJ, Hsieh VC, Hu SY. Medicine (Baltimore). 2016 Apr;95(16):e3388.
10. The pathological role of advanced glycation end products-downregulated heat shock protein 60 in islet β-cell hypertrophy and dysfunction. Guan SS, Sheu ML, Yang RS, Chan DC, Wu CT, Yang TH, Chiang CK, Liu SH. Oncotarget. 2016 Apr 26;7(17):23072-87. 【Impact Factor: 5.168, ONCOLOGY 44/127=20.29%, 2016JCR】
11. Iodinated Contrast Medium Exposure During Computed Tomography Increase the Risk of Subsequent Development of Thyroid Disorders in Patients Without Known Thyroid Disease: A Nationwide Population-Based, Propensity Score-Matched, Longitudinal Follow-Up Study. Hsieh MS, Chiu CS, Chen WC, Chiang JH, Lin SY, Lin MY, Chang SL, Sheu ML*, Hu SY*. Medicine (Baltimore). 2015 Dec;94(50):e2279. 【Impact Factor: 1.803, MEDICINE, GENERAL & INTERNAL 58/154=37.66%, 2016JCR】
12. Advanced glycation end-products induce skeletal muscle atrophy and dysfunction in diabetic mice via a RAGE-mediated, AMPK-down-regulated, Akt pathway. Chiu CY, Yang RS, Sheu ML, Chan DC, Yang TH, Tsai KS, Chiang CK, Liu SH. The Journal of Pathology. 2016 Feb;238(3):470-82. 【Impact Factor: 6.894, PATHOLOGY 3/79=3.79%, 2016JCR】 
13. Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBPβ and NFκB cleavage. Wu SM, Lin WY, Shen CC, Pan HC, Keh-Bin W, Chen YC, Jan YJ, Lai DW, Tang SC, Tien HR, Chiu CS, Tsai TC, Lai YL, Sheu ML*. Journal Of Pineal Research, 2016 Mar;60(2):142-54. 【Impact Factor:10.391, PHYSIOLOGY 3/84=3.57%, 2016JCR】 【研究生獲選-第12屆永信李天德醫藥科技獎-傑出論文獎】【研究生獲選-2017第14屆林榮耀教授學術教育基金會論文獎】
14. Aryl Hydrocarbon Receptor Deficiency Attenuates Oxidative Stress-Related Mesangial Cell Activation and Macrophage Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy. Lee WJ, Liu SH, Chiang CK, Lin SY, Liang KW, Chen CH, Tien HR, Chen PH, Wu JP, Tsai YC, Lai DW, Chang YC, Sheu WH, Sheu ML*. Antioxidants & Redox Signaling. 2016 Feb 1;24(4):217-231. 【Impact Factor: 6.337, ENDOCRINOLOGY & METABOLISM 13/138=9.42%, 2016JCR】
15. ATP synthase subunit-β down-regulation aggravates diabetic nephropathy. Guan SS, Sheu ML, Wu CT, Chiang CK, Liu SH. Scientific Reports. 2015 Oct 9;5:14561. 【Impact Factor: 4.259, MULTIDISCIPLINARY SCIENCES 10/64=15.625%, 2016JCR】 
16. Enhanced Allergic Inflammation of Der p 2 Affected by Polymorphisms of MD-2 Promoter. Liao EC, Hsieh CW, Chang CY, Yu SJ, Sheu ML, Wu SM, Tsai JJ. Allergy, Asthma & Immunology Research 2015 Sep;7(5):497-506.
17. Increased survival with the combination of stereotactic radiosurgery and gefitinib for non-small cell lung cancer brain metastasis patients: a nationwide study in Taiwan. Lin CH, Hsu KH, Chang SN, Tsou HK, Sheehan J, Sheu ML, Pan HC. Radiation Oncology 2015 Jun 6;10:127.
18. Correction: Correction: Cell-Penetrating Peptide Derived from Human Eosinophil Cationic Protein Inhibits Mite Allergen Der p 2 Induced Inflammasome Activation. Yu SJ, Liao EC, Sheu ML, Chang DT, Tsai JJ. PLoS One. 2015 Jun 1;10(6):e0129187.
19. Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model. Chen CJ, Cheng FC, Su HL, Sheu ML, Lu ZH, Chiang CY, Yang DY, Sheehan J, Pan HC. PLoS One. 2015 May 6;10(5):e0124624
20. Correction: Cell-Penetrating Peptide Derived from Human Eosinophil Cationic Protein Inhibits Mite Allergen Der p 2 Induced Inflammasome Activation. Yu SJ, Liao EC, Sheu ML, Margaret Chang DT, Tsai JJ. PLoS One. 2015 Apr 24;10(4):e0127255.
21.  Advanced glycation end-products induce apoptosis in pancreatic islet endothelial cells via NF-κB-activated cyclooxygenase-2/prostaglandin E2 up-regulation. Lan KC, Chiu CY, Kao CW, Huang KH, Wang CC, Huang KT, Tsai KS, Sheu ML*, Liu SH*. PLoS One. 2015 Apr 21;10(4):e0124418. 【Impact Factor: 3.057, MULTIDISCIPLINARY SCIENCES 15/64=17.46%, 2015JCR】
22. Cell-penetrating peptide derived from human eosinophil cationic protein inhibits mite allergen Der p2 induced inflammasome activation. Yu SJ, Liao EC, Sheu ML, Chang DT, Tsai JJ. PLoS One. 2015 Mar 25;10(3):e0121393. 【Impact Factor: 3.057, MULTIDISCIPLINARY SCIENCES 15/64=17.46%, 2015JCR】
23. Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition. Liu SH, Lee WJ, Lai DW, Wu SM, Liu CY, Tien HR, Chiu CS, Peng YC, Jan YJ, Chao TH, Pan HC, Sheu ML*. Molecular Oncology. 2015 Apr;9(4):834-49. 【Impact Factor:5.331, ONCOLOGY 28/211=13.27%, 2014JCR】
24. The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination. Lai DW, Liu SH, Karlsson AI, Lee WJ, Wang KB, Chen YC, Shen CC, Wu SM, Liu CY, Tien HR, Peng YC, Jan YJ, Chao TH, Lan KH, Arbiser JL, Sheu ML* Oncotarget. 2014 Sep 15;5(17):7788-804. 【Impact Factor: 6.359, ONCOLOGY 21/211=9.95%, 2014JCR】
25. Deletion of the gene encoding the reductase component of 3-ketosteroid 9α-hydroxylase in Rhodococcus equi USA-18 disrupts sterol catabolism, leading to the accumulation of 3-oxo-23,24-bisnorchola-1,4-dien-22-oic acid and 1,4-androstadiene-3,17-dione. Yeh CH, Kuo YS, Chang CM, Liu WH, Sheu ML, Meng M. Microbial Cell Factories. 2014 Sep 9;13:130. doi: 10.1186/s12934-014-0130-3.
26. CCAAT-Enhancer-Binding Protein Homologous Protein Deficiency Attenuates Oxidative Stress and Renal Ischemia-Reperfusion Injury. Chen BL, Sheu ML, Tsai KS, Lan KC, Guan SS, Wu CT, Chen LP, Hung KY, Huang JW, Chiang CK, Liu SH. Antioxidants & Redox Signaling. 2015 Nov 20;23(15):1233-45. 【Impact Factor: 7.407, ENDOCRINOLOGY & METABOLISM 10/128=7.75%, 2014JCR】
27. Nε-carboxymethyllysine-mediated endoplasmic reticulum stress promotes endothelial cell injury through Nox4/MKP-3 interaction. Lee WJ, Sheu WH, Liu SH, Yi YC, Chen WC, Lin SY, Liang KW, Shen CC, Yeh HY, Lin LY, Tsai YC, Tien HR, Lee MR, Yang TJ, Sheu ML* Free Radical Biology and Medicine. 2014 Sep;74:294-306. 【Impact Factor: 5.736, ENDOCRINOLOGY & METABOLISM 16/128=12.5%, 2014JCR】
28. Detection of subtle neurological alterations by the Catwalk XT gait analysis system. Chen YJ, Cheng FC, Sheu ML, Su HL, Chen CJ, Sheehan J, Pan HC. Journal of NeuroEngineering and Rehabilitation. 2014 Apr 16;11:62.
29. Comprehensive analysis of neurobehavior associated with histomorphological alterations in a chronic constrictive nerve injury model through use of the CatWalk XT system. Chiang CY, Sheu ML, Cheng FC, Chen CJ, Su HL, Sheehan J, Pan HC. Journal of Neurosurgery. 2014 Jan;120(1):250-62.
30.  Tpl2 inhibitors thwart endothelial cell function in angiogenesis and peritoneal dissemination. Lee WJ, Lan KH, Chou CT, Yi YC, Chen WC, Pan HC, Peng YC, Wang KB, Chen YC, Chao TH, Tien HR, Sheu WH, Sheu ML*. Neoplasia. 2013 Sep;15(9):1036-48. 【Impact Factor: 4.252, ONCOLOGY 49/211=23.22%, 2014JCR】
31. Reciprocal modulation of C/EBP-α and C/EBP-β by IL-13 in activated microglia prevents neuronal death. Pan HC, Yang CN, Hung YW, Lee WJ, Tien HR, Shen CC, Sheehan J, Chou CT, Sheu ML*. European Journal of Immunology. 2013 Nov;43(11):2854-65. 【Impact Factor: 4.034, IMMUNOLOGY 39/148=26.35%, 2014JCR】
32. Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model. Pan HC, Lai DW, Lan KH, Shen CC, Wu SM, Chiu CS, Wang KB, Sheu ML*. Carcinogenesis. 2013 Nov;34(11):2568-79. 【Impact Factor: 5.334, ONCOLOGY 27/211=12.79%, 2014JCR】
33. Advanced glycation end products induce peroxisome proliferator-activated receptor γ down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor for advanced glycation end products. Chen YJ, Sheu ML, Tsai KS, Yang RS, Liu SH. PLoS One. 2013 Jun 12;8(6):e66611. 【Impact Factor: 3.234, MULTIDISCIPLINARY SCIENCES 9/57=15.78%, 2014JCR】
34. Mechanism of maprotiline-induced apoptosis: role of [Ca2+](i), ERK, JNK and caspase-3 signaling pathways. Jan CR, Su JA, Teng CC, Sheu ML, Lin PY, Chi MC, Chang CH, Liao WC, Kuo CC, Chou CT. Toxicology. 2013 Feb 8;304:1-12.
35. Intracapsular decompression or radical resection followed by Gamma Knife surgery for patients harboring a large vestibular schwannoma. Pan HC, Sheehan J, Sheu ML, Chiu WT, Yang DY. Journal of Neurosurgery 2012 Dec;117 Suppl:69-77.
36. Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. Liu SH, Wang KB, Lan KH, Lee WJ, Pan HC, Wu SM, Peng YC, Chen YC, Shen CC, Cheng HC, Liao KK, Sheu ML*. PLoS One. 2012;7(8):e43711. 【Impact Factor: 3.234, MULTIDISCIPLINARY SCIENCES 9/57=15.78%, 2014JCR】
37. Advanced glycation end product Nε-carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation. Liu SH, Sheu WH, Lee MR, Lee WJ, Yi YC, Yang TJ, Jen JF, Pan HC, Shen CC, Chen WB, Tien HR, Sheu ML*. The Journal of Pathology. 2013 Jun;230(2):215-27. 【Impact Factor: 7.429, PATHOLOGY 4/76=5.26 %, 2014JCR】
38. Intracapsular decompression or radical resection followed by Gamma Knife surgery for patients harboring a large vestibular schwannoma. Pan HC, Sheehan J, Sheu ML, Chiu WT, Yang DY. JOURNAL OF NEUROSURGERY. 2012 Dec;117 Suppl:69-77.
39.  Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. Liu SH, Wang KB, Lan KH, Lee WJ, Pan HC, Wu SM, Peng YC, Chen YC, Shen CC, Cheng HC, Liao KK, Sheu ML* PLoS One. 2012;7(8):e43711.
40. Dual regeneration of muscle and nerve by intravenous administration of human amniotic fluid-derived mesenchymal stem cells regulated by stromal cell-derived factor-1α in a sciatic nerve injury model. Yang DY, Sheu ML, Su HL, Cheng FC, Chen YJ, Chen CJ, Chiu WT, Yiin JJ, Sheehan J, Pan HC. JOURNAL OF NEUROSURGERY. 2012 Jun;116(6):1357-67.
41. Recruitment by SDF-1α of CD34-positive cells involved in sciatic nerve regeneration. Sheu ML, Cheng FC, Su HL, Chen YJ, Chen CJ, Chiang CM, Chiu WT, Sheehan J, Pan HC. JOURNAL OF NEUROSURGERY. 2012 Feb;116(2):432-44.
42. Mite allergen Der-p2 triggers human B lymphocyte activation and Toll-like receptor-4 induction. Tsai JJ, Liu SH, Yin SC, Yang CN, Hsu HS, Chen WB, Liao EC, Lee WJ, Pan HC, Sheu ML*. PLoS One. 2011;6(9):e23249.
43. Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model. Wu CT, Sheu ML, Tsai KS, Chiang CK, Liu SH. FREE RADICAL BIOLOGY AND MEDICINE. 2011 Aug 1;51(3):671-80.
44. Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response. Pan HC, Sheu ML, Su HL, Chen YJ, Chen CJ, Yang DY, Chiu WT, Cheng FC. MAGNESIUM RESEARCH 2011 Jun;24(2):54-70.
45. Honokiol inhibits hypoxia-inducible factor-1 pathway. Lan KL, Lan KH, Sheu ML, Chen MY, Shih YS, Hsu FC, Wang HM, Liu RS, Yen SH. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2011 Jun;87(6):579-90.
46. Honokiol ameliorates renal fibrosis by inhibiting extracellular matrix and pro-inflammatory factors in vivo and in vitro. Chiang CK, Sheu ML, Lin YW, Wu CT, Yang CC, Chen MW, Hung KY, Wu KD, Liu SH. BRITISH JOURNAL OF PHARMACOLOGY. 2011 Jun;163(3):586-97.
47. Quality-of-life outcomes after Gamma Knife surgery for trigeminal neuralgia. Pan HC, Sheehan J, Huang CF, Sheu ML, Yang DY, Chiu WT. JOURNAL OF NEUROSURGERY. 2010 Dec;113 Suppl:191-8.
48. Radiosurgery for dural carotid-cavernous sinus fistulas: Gamma Knife compared with XKnife radiosurgery. Pan HC, Sun MH, Sheehan J, Sheu ML, Chen CC, Lee HT, Chiu WT, Yang DY. JOURNAL OF NEUROSURGERY. 2010 Dec;113 Suppl:9-20.
49. Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals. Liu SH, Shen CC, Yi YC, Tsai JJ, Wang CC, Chueh JT, Lin KL, Lee TC, Pan HC, Sheu ML* BRITISH JOURNAL OF PHARMACOLOGY. 2010 Aug;160(8):1963-72.
50. IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death. Liu SH, Yang CN, Pan HC, Sung YJ, Liao KK, Chen WB, Lin WZ, Sheu ML* CELLULAR AND MOLECULAR LIFE SCIENCES. 2010 May;67(9):1465-76.
51. The role of endoplasmic reticulum stress-related unfolded protein response in the radiocontrast medium-induced renal tubular cell injury. Wu CT, Sheu ML, Tsai KS, Weng TI, Chiang CK, Liu SH. TOXICOLOGICAL SCIENCES. 2010 Apr;114(2):295-301.
52.  Enhancement of regeneration with glia cell line-derived neurotrophic factor-transduced human amniotic fluid mesenchymal stem cells after sciatic nerve crush injury. Cheng FC, Tai MH, Sheu ML, Chen CJ, Yang DY, Su HL, Ho SP, Lai SZ, Pan HC. JOURNAL OF NEUROSURGERY. 2010 Apr;112(4):868-79.
53.  Escalated regeneration in sciatic nerve crush injury by the combined therapy of human amniotic fluid mesenchymal stem cells and fermented soybean extracts, Natto. Pan HC, Yang DY, Ho SP, Sheu ML, Chen CJ, Hwang SM, Chang MH, Cheng FC. JOURNAL OF BIOMEDICAL SCIENCE. 2009 Aug 23;16:75.
54. Potentiation of angiogenesis and regeneration by G-CSF after sciatic nerve crush injury. Pan HC, Wu HT, Cheng FC, Chen CH, Sheu ML, Chen CJ. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009 Apr 24;382(1):177-82.
55.  Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis. Sheu ML, Chiang CK, Tsai KS, Ho FM, Weng TI, Wu HY, Liu SH. FREE RADICAL BIOLOGY AND MEDICINE. 2008 Jun 15;44(12):2043-50.
56.  Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. Sheu ML*, Liu SH, Lan KH. PLoS ONE. 2007 Oct 31;2(10):e1096.
57. HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines. Lan KH, Lan KL, Lee WP, Sheu ML, Chen MY, Lee YL, Yen SH, Chang FY, Lee SD.  JOURNAL OF HEPATOLOGY 2007 May;46(5):759-67.
58. Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. Chiang CK, Sheu ML, Hung KY, Wu KD, S-H Liu. KIDNEY INTERNATIONAL. 2006 Aug;70(4):682-9.
59. The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population. Lee WP, Tai DI, Lan KH, Li AF, Hsu HC, Lin EJ, Lin YP, Sheu ML, Li CP, Chang FY, Chao Y, Yen SH, Lee SD. CLINICAL CANCER RESEARCH. 2005 Sep 15;11(18):6431-41.
60. Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the up-regulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells. Sheu ML, Chao KF, Sung YJ, Lin WW, Lin-Shiau SY , Liu SH. CELLULAR SIGNALLING. 2005 Aug;17(8):975-84. Epub 2004 Dec 15.
61. High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway. Sheu ML, Ho FM, Yang RS, Chao KF, Lin WW, Lin-Shiau SY, Liu SH. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005 Jan 25(3):539-45.
62. Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen species-related nuclear factor-kappaB activation and cyclooxygenase-2 expression in mesangial cells. Sheu ML, Ho FM, Chao KF, Kuo ML, Liu SH. MOLECULAR PHARMACOLOGY. 2004 Jul 66(1):187-96.
63. Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma. Chung YL, Sheu ML, Yen SH. INTERNATIONAL JOURNAL OF CANCER. 2003 Oct 20;107(1):65-73.
64. HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis. Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD. ONCOGENE. 2002 Jul 18;21(31):4801-11.
65. Resistance to tamoxifen-induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer. Chung YL, Sheu ML, Yang SC, Lin CH, Yen SH. INTERNATIONAL JOURNAL OF CANCER. 2002 Jan 20;97(3):306-12.