游勝傑

免疫學、風濕病學、皮膚醫學

上學期：幹細胞醫學與細胞治療特論、生物醫學新知與應用。

下學期：微菌轉譯醫學特論、仁醫講學：疾病預防、臨床檢驗與治療。

高雄榮民總醫院教學研究部契約高級助理研究員

臺中榮民總醫院醫學研究部契約副研究員

國立陽明交通大學中醫系教學空間落成典禮暨中醫藥實證科學研討會Honorable Poster Award

第19屆國際東洋醫學學術大會壁報論文第一名

A.期刊論文

1、Fang-Liang Huang, En-Chih Liao, Chia-Ling Li, Chung-Yang Yen*, Sheng-Jie Yu*. Pathogenesis of pediatric B-cell acute lymphoblastic leukemia: molecular pathways and disease treatments. Oncology Letters. ONCOLOGY LETTERS 2020; 20: 448-454. Review

2、Chung Yang Yen, Wen Dee Chiang, Shang Yong Liu, Sheng Jie Yu*, Ching Liang   Hsieh*. Shikonin inhibits Der p 2 induced cytokine and chemokine expression in   dendritic cells in patients with atopic dermatitis. Evidence-Based Complementary and Alternative Medicine 2020; 2020: 9506363.

3、Ching-Hsiang Yu, Jaw-Ji Tsai, Yi-Hsueh Lin, Sheng-Jie Yu, En-Chih Liao*. Identification the Cross-Reactive or Species-Specific Allergens of Tyrophagus putrescentiae and Development Molecular Diagnostic Kits for Allergic Diseases. Diagnostics 2020; 10: 665.

4、Fang-Liang Huang, Sheng-Jie Yu, Chia-Ling Li*. Role of Autophagy and Apoptosis in Acute Lymphoblastic Leukemia. Cancer Control 2021; 28: 1-8.

5、Yun-Ju Wang, Sheng-Jie Yu, Jaw-Ji Tsai, Ching-Hsiang Yu, En-Chih Liao*.Antagonism of Protease Activated Receptor-2 by GB88 Reduces Inflammation Triggered by Protease Allergen Tyr-p3. Front. Immunol 2021;12: 557433.

6、Pei-Wen Shen, Yu-Mei Chou, Chia-Ling Li, En-Chih Liao, Hung-Sen Huang, Chun-Hao Yin, Chien-Liang Chen, Sheng-Jie Yu*. Itraconazole improves survival in patients with colon cancer by inducing autophagic cell death and inhibiting transketolase expression. ONCOLOGY LETTERS 2021; 22: 768.

7、Fang-Liang Huang, Sheng-Jie Yu, En-Chih Liao, Long-Yuan Li, Pei-Wen Shen, Chia-Ling Li*. Niclosamide suppresses T‑cell acute lymphoblastic leukemia growth through activation of apoptosis and autophagy. ONCOLOGY REPORTS 2022; 47: 30.

8、Hsuan Lin, Chia-Ling Li, Ling-Jung Yen, Ling-Ying Lu, Hung-Sen Huang, En-Chih Liao, Sheng-Jie Yu*. Forsythoside A Alleviates Imiquimod-Induced Psoriasis-like Dermatitis in Mice by Regulating Th17 Cells and IL-17A Expression. J. Pers. Med 2022; 12: 62.

9、Chung-Yang Yen, Sheng-Jie Yu, Yi-Ming Chen, Kuo-Lung Lai , Yi-Da Wu, En-Chih Liao* and Ching-Liang Hsieh*. Mechanisms of Tumor Necrosis Factor-Alpha Inhibitor-Induced Systemic Lupus Erythematosus. Front. Med 2022; 9:870724.

10、Yi-Ping Chen, Chia-Ling Li, Hung-Sen Huang, Hsuan Lin*, Sheng-Jie Yu*. Emodin Ameliorates HDM-Induced Allergic Rhinitis in Mice by Decreasing Th2-Related Cytokine Expression. Show–Chwan Med J 2022; 21(2): 30-38.

11、Jaw‑Ji Tsai, Chung‑Yang Yen, Chun‑Hsien Hsu, Sheng‑Jie Yu, Chao‑Hsien Chen, En‑Chih Liao. Immunomodulatory effects of modified Liu‑Wei‑Di‑Huang‑Wan Traditional Chinese medicine on allergic asthmatic mice. Allergy, Asthma & Clinical Immunology. 2023; 19: 35.

12、Meng-Chieh Shih, Chia-Ling Li, En-Chih Liao, Chung-Yang Yen, Ling-Jung Yen, Kai-Chun Wang, Ling-Ying Lu, Ting-Yu Chou, Ying-Chin Chen, Sheng-Jie Yu*. Inhibition of NLRP3 Inflammasome Activation by 3H-1,2-Dithiole-3-Thione: A Potential Therapeutic Approach for Psoriasis Treatment. Int. J. Mol. Sci. 2023, 24, 13528.

13、Ling-Jung Yen, Ying-Chin Chen, Kai-Chun Wang, Meng-Chieh Shih, Chia-Ling Li, Sheng-Jie Yu*, Ling-Ying Lu*. Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes. Immunopharmacol Immunotoxicol. 2024, 46, (1): 128–137.

14、Fang-Liang Huang, Yao-Ming Chang, Cheng-Yung Lin, Sheng-Jie Yu, Jing-Tong Fu, Ting-Yu Chou, Sih-Wen Yeh, En-Chih Liao, Chia-Ling Li. Regulating TKT activity inhibits proliferation of human acute lymphoblastic leukemia cells. Am J Cancer Res 2024;14(2):679-695.

15、WEI‑FANG CHANG, PO‑WEI HUANG, CHIA‑LING LI, HUNG‑SEN HUANG, TING‑YU CHOU, EN‑CHIH LIAO*, SHENG‑JIE YU*. Radiocontrast medium induces histamine release in association with upregulation of miR‑19a‑3p and miR‑362‑3p expression. BIOMEDICAL REPORTS 2024; 20: 93.

16、Ching-Liang Hsieh, Sheng-Jie Yu, Kuo-Lung Lai, Wei-Ting Chao, Chung-Yang Yen*. IFN-, IL-17A, IL-4, and IL-13: Potential Biomarkers for Prediction of the Effectiveness of Biologics in Psoriasis Patients. Biomedicines 2024, 12, 1115.

17、Chia-Ling Li, Han-Yu Chen, Jiin-Cherng Yen, Sheng-Jie Yu, Ting-Yu Chou, Sih-Wen Yeh, Huai-Yu Chuang, Fang-Liang Huang. Stattic suppresses p‑STAT3 and induces cell death in T‑cell acute lymphoblastic leukemia. Mol Med Rep. 2025 Feb;31(2):51.

18、Chia-Ling Li, Kuei-Ying Yen, Wen-Nan Huang, Chung-Yang Yen, Kai-Chun Wang, En-Chih Liao, Ting-Yu Chou, Hung-Sen Huang, Sheng-Jie Yu*. Brevilin A inhibits IL-17A-induced inflammation in psoriasis by modulating HSP 70. Mol Med Rep. 2025 Jun;31(6):156.

B.研討會論文

1. Kai-Chun Wang, Sheng-Jie Yu (2024, May). Role of brevilin A in ameliorating psoriasis through HSP70 modulation. 2024 SID Annual Meeting, 美國德州. Nstc 112-2314-B-075B-018. 本人為通訊作者.

2. 游勝傑 (2024, May). To Treat Psoriasis, Chinese Herbal Medicine Cannot be Absent. 20th Annual Congress of International Drug Discovery Science & Technology-2024(IDDST-2024), 日本大阪. 本人為通訊作者.

3. 石孟潔, 李佳玲, 廖恩慈, 閻忠揚, 顏伶容, 王愷君, 呂聆音, 周庭瑜, 陳映瑾, 游勝傑 (2024, Mar). Inhibition of NLRP3 Inflammasome Activation by 3H-1,2-Dithiole-3-Thione: A Potential Therapeutic Approach for Psoriasis Treatment. 第

38屆生物醫學聯合學術年會, 國防醫學院. 本人為通訊作者.

4. 陳映瑾, 王愷君, 顏伶容, 石孟潔, 李佳玲, 戴明泓, 游勝傑, 呂聆音 (2024,Mar). Mite allergy drives mast cells to amplify psoriatic inflammation: real world data and a murine model. 第38屆生物醫學聯合學術年會, 國防醫學院.本人為通訊作者.

5. 顏伶容, 陳映瑾, 王愷君, 石孟潔, 李佳玲, 游勝傑, 呂聆音 (2024, Mar).Hydroxychloroquine exacerbates imiquimod-induced psoriasis-like dermatitis through stimulating overexpression of IL-6 in keratinocytes. 第38屆生物醫學聯合學術年會, 國防醫學院. 本人為通訊作者.

6. 張維方、黃柏瑋、李佳玲、周庭瑜、游勝傑 (2023, Nov). Radiocontrast Medium Induced T cell activation by activating MAPK signaling pathway and microRNA expression. 第50屆國軍軍醫學術研討會. 本人為通訊作者.

7. Chung Yang Yen, Sheng Jie Yu (2023, May). Targeting NLRP3 inflammasome activation to inhibit skin inflammation and modulate Th17 cell differentiation for the treatment of psoriasis. International Societies for Investigative Dermatology (ISID) 2023, 日本東京. 本人為通訊作者.

8. 張維方、黃柏瑋、李佳玲、黃紘森、游勝傑 (2022, Nov). Radiocontrast Medium Induced Histamine Release by Upregulating miR-19a-3p and miR-362-3p expression. 第49屆國軍軍醫學術研討會. 本人為通訊作者.

9. Ling-Jung Yen, Chung-Yang Yen, Chia-Ling Li, En-Chih Liao, Kai-Chun Wang, Meng-Chieh Shih, Hung-Sen Huang, Ying-Chin Chen, Ling-Ying Lu, Sheng-Jie Yu (2022, Oct). Brevilin A as a novel therapeutic agent for treating psoriasis. 第14屆紀念王創辦人永慶先生學術研討會-2022長庚醫學週. nstc 110-2314-B-075B-003-MY2. 本人為通訊作者.

10. Fang-Liang Huang, Sheng-Jie Yu, Chia-Ling Li (2021, Nov). Niclosamide Exerts Anti-Leukemia Activity by Inhibiting Transketolase and Increasing Apoptosis in T-Cell Acute Lymphoblastic Leukemia. 14th Asia Pacific Federation of Pharmacologists, Taipei International Convention Center .

11. Sheng-Jie Yu, Chung-Yang Yen, Chia-Ling Li, Ling-Jung Yen, Ling-Ying Lu (2021, Nov). Brevilin A Inhibited IL-17A Induced Proinflammatory Cytokines Expression of Keratinocytes and Ameliorated Imiquimod Induced Psoriasis-liked Skin Inflammation . 14th Asia Pacific Federation of Pharmacologists (APFP2021) , Taipei International Convention Center . 本人為第一作者.

12. Hsuan Lin, Sheng-Jie Yu, Chia-Ling Li (2021, Apr). Forsythoside A alleviates imiquimod induced psoriasis-like dermatitis in mice through regulating IL-17A . 12th Asia-Pacific Forum of Medical Laboratory Sciences, 三軍總醫院.

13. Huai-Yu Chuang, Pei-Wen Shen, Sheng-Jie Yu, Chia-Ling Li (2021, Apr). Itraconazole suppresses proliferation of colon cancer cells through inhibiting transketolase expression and inducing autophagic cell death. 12th Asia-Pacific Forum of Medical Laboratory Sciences, 三軍總醫院.

 C.專書